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脊椎骨髓炎

Vertebral Osteomyelitis.

作者信息

McGee Alan W, Dean Chase S, Ignatiuk Ashley, Savelli Carla, Kleck Christopher J

机构信息

Department of Orthopaedic Surgery (Dr. McGee, Dr. Dean, and Dr. Kleck), The University of Colorado, Aurora, CO; the Division Plastics and Reconstructive (Dr. Ignatiuk), Department of Surgery, Rutgers New Jersey Medical School, Newark, NJ; and the Department of Infectious Diseases (Dr. Savelli), The University of Colorado School of Medicine, Aurora, CO.

出版信息

J Am Acad Orthop Surg Glob Res Rev. 2019 Dec 5;3(12). doi: 10.5435/JAAOSGlobal-D-18-00069. eCollection 2019 Dec.

Abstract

UNLABELLED

A report of an instance of vertebral osteomyelitis secondary to an uncommon pathogen, .

SUMMARY

is a rapidly growing nontuberculous osteomyelitis which is typically nonpathogenic with only four reported cases of human infection. Diagnosing infections related to nontuberculous mycobacteria (NTM) is difficult and can often be delayed as conventional microbiologic tests are inadequate. Currently, there are no consensus guidelines concerning the treatment of vertebral osteomyelitis caused by NTM. A 45-year-old man presented with chronic back pain and bilateral lower extremity radicular symptoms status-post lumbar fusion with previous deep infection. CT scan demonstrated incomplete union after fusion. He underwent irrigation and débridement on March 15, 2016, with tissue culture and biopsy. Given negative cultures and completion of a 6-week course of intravenous antibiotics, on May 3, 2016, he went for implant removal and repeat instrumentation. During the same hospitalization, deep spinal fluid acid-fast bacilli culture from March 15, 2016, came back positive at 8 weeks, identified as . He was started on an empiric 4-drug regimen for NTM which he continued for 12 months. There has been no recurrence of infection to date.

DISCUSSION

This case serves as the first description of osteomyelitis of the spine and as a reminder that proper diagnosis of infectious etiologies is necessary for adequate treatment.

摘要

未标注

一例由罕见病原体引起的脊椎骨髓炎报告。

总结

是一种快速生长的非结核性骨髓炎,通常无致病性,仅有4例人类感染报告。诊断与非结核分枝杆菌(NTM)相关的感染很困难,而且由于传统微生物检测不足,往往会延迟诊断。目前,对于由NTM引起的脊椎骨髓炎的治疗尚无共识性指南。一名45岁男性,既往有腰椎融合术伴深部感染病史,现出现慢性背痛和双侧下肢神经根症状。CT扫描显示融合后未完全愈合。2016年3月15日,他接受了冲洗和清创术,并进行了组织培养和活检。由于培养结果为阴性且完成了为期6周的静脉抗生素治疗,2016年5月3日,他接受了植入物取出和再次内固定手术。在同一住院期间,2016年3月15日的深部脊髓液抗酸杆菌培养在8周时呈阳性,鉴定为。他开始接受针对NTM的经验性四联药物治疗,并持续了12个月。迄今为止,感染未复发。

讨论

该病例是首例关于脊椎骨髓炎的描述,并提醒我们,对于充分治疗而言,正确诊断感染病因是必要的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a95a/7004494/040318975ccd/jaaos-glob-res-rev-3-e18.00069-g001.jpg

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