年龄和初始压缩对老年女性股骨力量松弛反应的影响。
The effect of age and initial compression on the force relaxation response of the femur in elderly women.
作者信息
Martelli Saulo
机构信息
Centre for Biomedical Technologies, School of Mechanical, Medical and Process Engineering, Queensland University of Technology (QUT), Brisbane, Australia.
Medical Device Research Institute, College of Science and Engineering, Flinders University, Tonsley SA, Australia.
出版信息
R Soc Open Sci. 2022 May 4;9(5):220301. doi: 10.1098/rsos.220301. eCollection 2022 May.
The effect of force amount, age, body weight and bone mineral density (BMD) on the femur's force relaxation response was analysed for 12 donors (age: 56-91 years). BMD and fracture load, , were estimated from clinical CT images. The 30 min force relaxation was obtained using a constant compression generating an initial force between 7% and 78% of . The stretched decay function (() = × ) proposed earlier for bone tissue was fitted to the data and analysed using robust linear regression. The relaxation function fitted well to all the recordings ( = 0.99). The relative initial force was bilinearly associated ( = 0.83) to the shape factor, , and the characteristic time, , when / was less than 0.4, although was no longer associated with / by pooling all the data. The characteristic time increased with age ( = 0.37, = 0.03) explaining 35% of the variation of in the entire dataset. In conclusion, the relative initial force mostly determines the femur's force relaxation response, although the early relaxation response under subcritical loading is variable, possibly due to damage occurring at subcritical loading levels.
分析了12名捐赠者（年龄：56 - 91岁）的力大小、年龄、体重和骨矿物质密度（BMD）对股骨力松弛反应的影响。从临床CT图像估计BMD和骨折负荷 。使用恒定压缩获得30分钟的力松弛，产生的初始力 在 的7%至78%之间。先前为骨组织提出的拉伸衰减函数（() = × ）对数据进行拟合，并使用稳健线性回归进行分析。松弛函数对所有记录拟合良好（ = 0.99）。当 / 小于0.4时，相对初始力与形状因子 和特征时间 呈双线性相关（ = 0.83），尽管通过汇总所有数据， 不再与 / 相关。特征时间 随年龄增加（ = 0.37， = 0.03），解释了整个数据集中 变化的35%。总之，相对初始力主要决定股骨的力松弛反应，尽管亚临界负荷下的早期松弛反应是可变的，可能是由于亚临界负荷水平下发生的损伤。
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