Wakida K
Nihon Sanka Fujinka Gakkai Zasshi. 1987 Mar;39(3):432-8.
The immunopotentiator OK-432 was injected intracutaneously, locally, or both, to patients with cervical cancer. The results were as follows: Histological changes: There was a marked increase in the infiltration of T3, Ia1, M1, Leu7 into the interstices surrounding the cancer and the regional lymphnodes. An analysis of the mononuclear cells in the regional lymphnodes by flow cytometry showed an increase in the percentage of M1 and Leu7. Cytotoxicity: There were significant increases in NK activity, LAK activity and killer activity in the mononuclear cells around the cancer and of the regional lymphnodes. These changes in the intracutaneous administration concomitantly with local administration were more marked than in the intracutaneous or local administration.
将免疫增强剂OK-432经皮内、局部或两者联合注射给宫颈癌患者。结果如下：组织学变化：癌灶及区域淋巴结周围间隙中T3、Ia1、M1、Leu7浸润明显增加。通过流式细胞术分析区域淋巴结中的单核细胞显示M1和Leu7百分比增加。细胞毒性：癌灶周围及区域淋巴结中的单核细胞的NK活性、LAK活性和杀伤活性显著增加。皮内注射与局部注射联合时的这些变化比单独皮内注射或局部注射时更明显。
