Ota H, Fukushima M, Maki M
Nihon Sanka Fujinka Gakkai Zasshi. 1987 Mar;39(3):471-8.
In order to understand the role of hormonal receptors in patients with hyperprolactinemia, changes in the ovarian receptors for prolactin and LH and in the serum hormone levels were studied in mature female rats. Wistar-Imamichi strain rats were pretreated with ovine prolactin (oPRL; 1IU), hCG (10IU) or hMG (20IU) for 4 days and oPRL, hCG, oPRL plus hCG for 8 days. The ovarian LH receptor levels fell significantly in rats stimulated with hCG, oPRL or hCG plus oPRL for 4 or 8 days. The serum estradiol level rose with hCG, and fell with oPRL. Combined treatment with oPRL and hCG synergistically reduced LH receptor to below the control level, and the estradiol level near the control compared with that by hCG alone. A decrease in LH receptor (60%) after the 4-day treatment with oPRL was further lowered to 53% of the control level after the 8 day treatment. Prolactin receptor levels rose with hCG after the 4-day administration, and then returned to normal after the 8-day treatment. The hMG treatment for 4 days raised the serum estradiol and progesterone levels to 9 times and twice those of the controls, respectively, without changing ovarian receptor levels. Prolactin seems to lower the ovarian LH receptor levels under certain conditions, and this may be one of the causes of the refractory reaction to gonadotropin therapy in patients with hyperprolactinemia.
为了解激素受体在高催乳素血症患者中的作用，对成年雌性大鼠的卵巢催乳素受体、促黄体生成素（LH）受体以及血清激素水平的变化进行了研究。将Wistar-Imamichi品系大鼠分别用羊催乳素（oPRL；1IU）、人绒毛膜促性腺激素（hCG；10IU）或人绝经期促性腺激素（hMG；20IU）预处理4天，并用oPRL、hCG、oPRL加hCG预处理8天。用hCG、oPRL或hCG加oPRL刺激4天或8天的大鼠，其卵巢LH受体水平显著下降。血清雌二醇水平在hCG刺激下升高，在oPRL刺激下降低。oPRL与hCG联合治疗可协同降低LH受体水平至对照水平以下，雌二醇水平与单独使用hCG时相比接近对照水平。用oPRL治疗4天后LH受体减少60%，治疗8天后进一步降至对照水平的53%。给药4天后，hCG可使催乳素受体水平升高，8天后恢复正常。hMG治疗4天可使血清雌二醇和孕酮水平分别升至对照水平的9倍和2倍，而不改变卵巢受体水平。催乳素在某些情况下似乎会降低卵巢LH受体水平，这可能是高催乳素血症患者对促性腺激素治疗产生难治性反应的原因之一。
