Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Navi Mumbai 400614, India.
Curr Drug Targets. 2022;23(10):960-977. doi: 10.2174/1573399818666220421123142.
Recent discoveries have unfolded many powerful emerging applications in the field of drug delivery science. For the past few years, ultrasound mediated microbubble contrast agents have been an emerging modality for diagnostic and drug delivery applications. Microbubbles are small spherical bubbles composed of a gas core encapsulated by a shell with different materials. The composition of the microbubble determines its stiffness, encapsulation efficiency, stability, and clearance from the system. A gas-filled microbubble, when activated by an acoustic pulse, can produce large volumetric oscillations and, once administered intravenously, can act as a cavitating nuclei, allowing for a wide range of ultrasound-assisted drug delivery applications. Microbubbles offer a fantastic approach to ultrasound triggered drug delivery with various drug loading techniques and targeting strategies for the uptake of bioactive substances such as polynucleotides, proteins, genes, and small-molecule drugs. Microbubbles can be used for several diagnostic and therapeutic purposes for accurate detection and treatment of various life-threatening diseases.
近年来，药物输送科学领域涌现出许多强大的新兴应用。在过去的几年中，超声介导的微泡造影剂已经成为一种用于诊断和药物输送应用的新兴模式。微泡是由气体核被不同材料的壳包裹而成的小球状气泡。微泡的组成决定了它的硬度、包封效率、稳定性和从系统中的清除率。充满气体的微泡在声脉冲的激活下可以产生大的体积振动，一旦静脉内给药，就可以作为空化核，从而实现广泛的超声辅助药物输送应用。微泡为超声触发药物输送提供了一种极好的方法，可采用各种药物负载技术和靶向策略，用于摄取多核苷酸、蛋白质、基因和小分子药物等生物活性物质。微泡可用于多种诊断和治疗目的，以准确检测和治疗各种危及生命的疾病。
