Sarrat P, Serise J M, Freyburger G, Lorient-Roudaut M F, Boisseau M R
J Mal Vasc. 1987;12(1):113-6.
Hemorheologic disorders are a frequent finding in circulating blood during vascular diseases (arterial disease of lower limb, cerebrovascular accidents). They participate in thrombogenesis and tissue ischemia production, and also in microcirculatory disturbances as shown by behavior in microvessels of red cells with decreased hereditary deformability (sickle cell anemia). Active alterations in erythrocyte rheology have also been demonstrated during vascular diseases in relation to inflammation: cell-protein inflammatory reaction, action of leukocytes. Therapy should be adapted for these microcirculatory disorders by suitable specific clinical trials.
血液流变学紊乱在血管疾病(如下肢动脉疾病、脑血管意外)的循环血液中很常见。它们参与血栓形成和组织缺血的产生,也参与微循环障碍,如遗传性变形能力降低的红细胞在微血管中的表现(镰状细胞贫血)所示。在与炎症相关的血管疾病中,也证实了红细胞流变学的活跃改变:细胞-蛋白质炎症反应、白细胞的作用。应通过适当的特定临床试验来针对这些微循环障碍进行治疗。