J Vis Exp. 2022 May 20(183). doi: 10.3791/6500.
An erratum was issued for: A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease. The Introduction and Protocol were updated. The first sentence of the Introduction was updated from: Inflammatory bowel diseases (IBD) such as Crohn's disease (CD) are chronic inflammatory disorders of the gastrointestinal tract affecting approximately 20 per 1,00,000 in Europe and USA. CD is characterized by transmural inflammation, intestinal fibrosis, and luminal stenosis. to: Inflammatory bowel diseases (IBD) such as Crohn's disease (CD) are chronic inflammatory disorders of the gastrointestinal tract affecting approximately 20 per 1,000,000 in Europe and USA. CD is characterized by transmural inflammation, intestinal fibrosis, and luminal stenosis. Step 1.3 in the Protocol was updated from: Prepare fresh TNBS solution according to body weights. NOTE: TNBS - 65 mg/kg of body weight in 250 µL of 40% ethanol was used. to: Prepare fresh TNBS solution according to body weights. NOTE: TNBS - 65 mg/kg of body weight in 250 µL of 40% ethanol/saline was used.
TNBS 诱导的啮齿动物模型研究机械应激在克罗恩病中的致病作用。更新了引言和方案。引言的第一句话从：炎症性肠病（IBD），如克罗恩病（CD），是影响欧洲和美国约每 1000000 人 20 人的胃肠道慢性炎症性疾病。CD 的特征是透壁炎症、肠纤维化和管腔狭窄。更新为：炎症性肠病（IBD），如克罗恩病（CD），是影响欧洲和美国约每 1000000 人 20 人的胃肠道慢性炎症性疾病。CD 的特征是透壁炎症、肠纤维化和管腔狭窄。方案中的步骤 1.3 从：根据体重准备新鲜的 TNBS 溶液。注：TNBS-65mg/kg 体重在 250µL 的 40%乙醇中使用。更新为：根据体重准备新鲜的 TNBS 溶液。注：TNBS-65mg/kg 体重在 250µL 的 40%乙醇/盐水中使用。
Zotero 插件