Lu Yan-Jhen, Chen Ssu-Yuan, Lai Ying-Chuen, Chaiyawat Pakaratee, Chao Yuan-Hung, Chuang Lee-Ming, Shih Tiffany Ting-Fang, Wang Hsing-Kuo
School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei, Taiwan.
Center of Physical Therapy, National Taiwan University Hospital, Taipei, Taiwan.
Metab Syndr Relat Disord. 2022 Sep;20(7):405-413. doi: 10.1089/met.2021.0101. Epub 2022 May 20.
The role of impaired oxygen extraction on peak oxygen uptake (O) has been extensively studied using noninvasive and indirect methods in both diabetic patients and healthy participants. A total of 22 participants with type 2 diabetes mellitus [T2DM; median (range) age: 60 (47-70) years] and 22 controls [58 (52-69) years] with no history of diabetes were recruited (reference no. 201812135RINB). Subjects performed an exhaustive incremental exercise and were evaluated using a gas analyzer and near-infrared spectroscopy (NIRS) to determine O and changes in muscle oxygenation (SmO) in the vastus lateralis, respectively. Measurements were taken at rest, warm-up, a period during exercise when SmO reached a minimum saturation plateau, and recovery. The microcirculatory responses of the vastus lateralis muscle during incremental exercise in patients with T2DM were compared with those in control individuals, and the correlation between changes in SmO and O was estimated. The diabetic group demonstrated lower O, peak workload, peak heart rate, peak minute ventilation (all < 0.05), and lower SmO during the rest, warm-up, and recovery phases (all < 0.05) compared with the control group. A correlation was observed between the change in SmO between the warm-up and plateau value and the O ( = 0.608, = 0.006). The results obtained in this study using NIRS support the feasibility of directly measuring changes in muscle SmO magnitudes to estimate the contributions of peripheral active muscle to systemic O uptake (O) during incremental exercise.
在糖尿病患者和健康参与者中，已使用非侵入性间接方法广泛研究了氧摄取受损对峰值摄氧量（O₂）的作用。招募了22名2型糖尿病（T2DM）患者[年龄中位数（范围）：60（47 - 70）岁]和22名无糖尿病史的对照者[58（52 - 69）岁]（参考文献编号201812135RINB）。受试者进行了力竭性递增运动，并分别使用气体分析仪和近红外光谱（NIRS）进行评估，以测定O₂和股外侧肌的肌肉氧合（SmO₂）变化。在静息、热身、运动期间SmO₂达到最低饱和平台期的时段以及恢复阶段进行测量。比较了T2DM患者在递增运动期间股外侧肌的微循环反应与对照个体的反应，并估计了SmO₂变化与O₂之间的相关性。与对照组相比，糖尿病组在静息、热身和恢复阶段的O₂、峰值工作量、峰值心率、峰值每分通气量均较低（均P < 0.05），且SmO₂也较低（均P < 0.05）。在热身至平台期的SmO₂变化与O₂之间观察到相关性（r = 0.608，P = 0.006）。本研究使用NIRS获得的结果支持了直接测量肌肉SmO₂大小变化以估计递增运动期间外周活跃肌肉对全身O₂摄取（O₂）贡献的可行性。
