Department of Biomedical Engineering, Meybod University, Meybod, Iran.
Department of Biomedical Engineering, Meybod University, Meybod, Iran.
Tissue Cell. 2022 Jun;76:101821. doi: 10.1016/j.tice.2022.101821. Epub 2022 May 13.
Regenerative medicine is recognized as one of the developing sciences in the world. Repair of bone injuries using stem cells and biomaterials has been considered by reconstructive medicine researchers in recent years. Biomechanical environments play a predominant role from cells to tissues and organs. These environments are also effective in the process of bone repair. Mechanical signals control biological activity at the site of injury. These signals regulate the formation, differentiation and proliferation of different cells. They are also responsible for the formation of connective tissue and the stabilization of damaged bone. Mechanical signals are applied to cells through external or internal factors. In this review, we first introduce and review the effective and active forces in determining the fate of stem cells such as Shear Stress, Tension, Elasticity, Stiffness, etc. Then we analyze the evidence from experimental studies and clinical observations about the effect of mechanobiology on bone repair or targeted differentiation of stem cells. We have also summarized the studies conducted in recent years in several tables.
再生医学被公认为世界上发展迅速的科学之一。近年来，利用干细胞和生物材料修复骨骼损伤已成为重建医学研究人员关注的焦点。生物力学环境从细胞到组织和器官都起着主导作用。这些环境在骨修复过程中也具有重要作用。机械信号控制损伤部位的生物活性。这些信号调节不同细胞的形成、分化和增殖。它们还负责结缔组织的形成和受损骨骼的稳定。机械信号通过外部或内部因素传递给细胞。在这篇综述中，我们首先介绍和回顾了剪切力、张力、弹性、硬度等决定干细胞命运的有效和活跃力，然后分析了关于机械生物学对骨修复或干细胞靶向分化影响的实验研究和临床观察证据。我们还总结了近年来在几个表格中进行的研究。
