Central Laboratory, Peking University School and Hospital of Stomatology, Beijing, 100081, P. R. China.
School of Medical and Life Sciences, Sunway University, Darul Ehsan, Selangor, 47500, Malaysia.
Adv Sci (Weinh). 2023 Jan;10(2):e2204502. doi: 10.1002/advs.202204502. Epub 2022 Dec 1.
Bone degeneration associated with various diseases is increasing due to rapid aging, sedentary lifestyles, and unhealthy diets. Living bone tissue has bioelectric properties critical to bone remodeling, and bone degeneration under various pathological conditions results in significant changes to these bioelectric properties. There is growing interest in utilizing biomimetic electroactive biomaterials that recapitulate the natural electrophysiological microenvironment of healthy bone tissue to promote bone repair. This review first summarizes the etiology of degenerative bone conditions associated with various diseases such as type II diabetes, osteoporosis, periodontitis, osteoarthritis, rheumatoid arthritis, osteomyelitis, and metastatic osteolysis. Next, the diverse array of natural and synthetic electroactive biomaterials with therapeutic potential are discussed. Putative mechanistic pathways by which electroactive biomaterials can mitigate bone degeneration are critically examined, including the enhancement of osteogenesis and angiogenesis, suppression of inflammation and osteoclastogenesis, as well as their anti-bacterial effects. Finally, the limited research on utilization of electroactive biomaterials in the treatment of bone degeneration associated with the aforementioned diseases are examined. Previous studies have mostly focused on using electroactive biomaterials to treat bone traumatic injuries. It is hoped that this review will encourage more research efforts on the use of electroactive biomaterials for treating degenerative bone conditions.
由于人口老龄化加速、生活方式久坐不动和饮食不健康，与各种疾病相关的骨退化正在增加。有生命力的骨组织具有对骨重塑至关重要的生物电学特性，而在各种病理条件下的骨退化会导致这些生物电学特性发生显著变化。利用仿生电活性生物材料来模拟健康骨组织的自然电生理微环境以促进骨修复的兴趣日益浓厚。这篇综述首先总结了与 II 型糖尿病、骨质疏松症、牙周炎、骨关节炎、类风湿性关节炎、骨髓炎和转移性溶骨性疾病等各种疾病相关的退行性骨病的病因。接下来，讨论了具有治疗潜力的多种天然和合成电活性生物材料。批判性地检查了电活性生物材料减轻骨退化的可能机制途径，包括增强成骨和血管生成、抑制炎症和破骨细胞生成，以及它们的抗菌作用。最后，检查了电活性生物材料在治疗上述疾病相关骨退化方面的有限研究。以前的研究主要集中在使用电活性生物材料治疗外伤性骨损伤。希望这篇综述将鼓励更多关于电活性生物材料治疗退行性骨病的研究工作。
