Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mol Biol Rep. 2022 Jul;49(7):6475-6481. doi: 10.1007/s11033-022-07476-0. Epub 2022 May 20.
Pancreatic cancer is a cancer with an insidious course. Since disease is often diagnosed at advanced stages, clinical outcome is impaired. Thus identification of biomarkers for this malignancy has importance in enhancement of patients' survival.
In the current study, we assessed expression levels of miR-8073 and miR-642 in the circulation of 50 patients with pancreatic cancer and 50 controls. Plasma levels of miR-8073 and miR-642 were significantly higher in patients with pancreatic cancer compared with controls (P value < 0.0001 and P value = 0.0068, respectively). Plasma levels of miR-642 were inversely correlated with albumin levels (R=-0.28, P value = 0.049), WBC count (R=-0.35, P value = 0.01), as well as CRP level (R=-0.30, P value = 0.035). On the other hand, levels of this miRNA were positively correlated with lipase level (R = 0.29, P value = 0.042). Levels of miR-8073 were not correlated with any of the available parameters. Plasma levels of miR-8073 could separate patients with pancreatic cancer from controls with AUC, sensitivity and specificity values of 0.82, 0.77 and 0.78, respectively. miR-642 could differentiate these two groups with AUC, sensitivity and specificity values of 0.63, 0.58 and 0.78, respectively. Combination of these two parameters resulted in AUC, sensitivity and specificity values of 0.79, 0.77 and 0.78, respectively.
Taken together, these two miRNAs are suggested as possible blood markers for pancreatic cancer.
胰腺癌是一种隐匿性很强的癌症。由于疾病通常在晚期才被诊断出来，因此临床预后受到影响。因此，鉴定这种恶性肿瘤的生物标志物对于提高患者的生存率具有重要意义。
在本研究中，我们评估了 50 名胰腺癌患者和 50 名对照者循环中 miR-8073 和 miR-642 的表达水平。与对照组相比，胰腺癌患者的血浆 miR-8073 和 miR-642 水平显著升高（P 值均<0.0001 和 P 值=0.0068）。miR-642 的血浆水平与白蛋白水平（R=-0.28，P 值=0.049）、白细胞计数（R=-0.35，P 值=0.01）以及 CRP 水平（R=-0.30，P 值=0.035）呈负相关。另一方面，miRNA 的水平与脂肪酶水平呈正相关（R=0.29，P 值=0.042）。miR-8073 的水平与所有可用参数均无相关性。miR-8073 的血浆水平能够以 AUC、敏感性和特异性值为 0.82、0.77 和 0.78 将胰腺癌患者与对照组区分开来。miR-642 能够以 AUC、敏感性和特异性值为 0.63、0.58 和 0.78 将这两组区分开来。将这两个参数结合起来，得到的 AUC、敏感性和特异性值分别为 0.79、0.77 和 0.78。
综上所述，这两种 miRNA 可作为胰腺癌的潜在血液标志物。
