Dugan Sarah P, Demirci Hakan
Kellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan, 1000 Wall St, Ann Arbor, MI, 48105, USA.
Int J Retina Vitreous. 2022 May 20;8(1):31. doi: 10.1186/s40942-022-00383-3.
Dapsone is a synthetic sulfonamide used to treat numerous dermatologic conditions. Ocular side effects have been rarely reported and include retinal necrosis, optic atrophy, and macular infarction. We report the first known case of bilateral choroidal effusions and exudative retinal detachments associated with dapsone use.
A 57-year-old male with a past medical history of testicular seminoma presented with bilateral blurry vision for 2 months. His exam revealed bilateral choroidal effusions with bilateral exudative retinal detachments without evidence of intraocular tumor. The patient had recently been prescribed dapsone for urticarial vasculitis. The patient was instructed to discontinue dapsone and follow-up closely. Interval follow-up of 8 months demonstrated almost complete resolution of the choroidal effusions and retinal detachments with residual pigment epithelium changes after cessation of dapsone. The patient recovered his pre-detachment visual function.
Patients on dapsone who present with new visual complaints should undergo a thorough ophthalmic evaluation given the multiple mechanisms by which dapsone can affect the eye.
氨苯砜是一种用于治疗多种皮肤病的合成磺胺类药物。眼部副作用鲜有报道，包括视网膜坏死、视神经萎缩和黄斑梗死。我们报告首例已知的与使用氨苯砜相关的双侧脉络膜积液和渗出性视网膜脱离病例。
一名57岁男性，有睾丸精原细胞瘤病史，出现双侧视力模糊2个月。检查发现双侧脉络膜积液伴双侧渗出性视网膜脱离，无眼内肿瘤证据。该患者最近因荨麻疹性血管炎被开具氨苯砜。患者被指示停用氨苯砜并密切随访。8个月的间隔随访显示，脉络膜积液和视网膜脱离几乎完全消退，氨苯砜停用后残留色素上皮改变。患者恢复了脱离前的视觉功能。
鉴于氨苯砜可通过多种机制影响眼睛，使用氨苯砜且出现新的视觉症状的患者应接受全面的眼科评估。
