Key Laboratory of Smart Drug Delivery, Ministry of Education, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, China.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2022 Sep;14(5):e1818. doi: 10.1002/wnan.1818. Epub 2022 May 20.
Brain diseases, including neurodegenerative diseases, acute ischemic stroke and brain tumors, have become a major health problem and a huge burden on society with high morbidity and mortality. However, most of the current therapeutic drugs can only relieve the symptoms of brain diseases, and it is difficult to achieve satisfactory therapeutic effects fundamentally. Extensive studies have shown that the therapeutic effects of brain diseases are mainly affected by two factors: the conservation of the blood-brain barrier (BBB) and the complexity of the brain micro-environment. Brain-targeting drug delivery systems provide new possibilities for overcoming these barriers with versatility. In this review, it provides an overview of BBB alteration and discusses targeting delivery strategies for brain diseases therapy. Furthermore, delivery systems which are designed to modulate the brain micro-environment with synergistic effects were also highlighted. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies.
脑部疾病，包括神经退行性疾病、急性缺血性中风和脑肿瘤，已成为一个主要的健康问题，并给社会带来了高发病率和死亡率的巨大负担。然而，目前大多数治疗药物只能缓解脑部疾病的症状，很难从根本上达到令人满意的治疗效果。广泛的研究表明，脑部疾病的治疗效果主要受两个因素的影响：血脑屏障（BBB）的保护和大脑微环境的复杂性。脑部靶向药物传递系统为克服这些障碍提供了新的可能性。在这篇综述中，它概述了 BBB 的改变，并讨论了针对脑部疾病治疗的靶向传递策略。此外，还强调了旨在通过协同作用调节大脑微环境的传递系统。本文属于以下类别：治疗方法和药物发现 > 新兴技术。
