Synthesis of Multicompartment Nanoparticles of Block Copolymer through Two Macro-RAFT Agents Co-Mediated Dispersion Polymerization.

A new and efficient strategy to synthesize multicompartment block copolymer nanoparticles (MCBNs) by two macro-RAFT agents comediated dispersion polymerization is proposed. By simultaneously employing two macro-RAFT agents in dispersion RAFT polymerization, one-pot synthesis of well-defined MCBNs constructed with two diblock copolymers of poly(-butyl methyl acrylate)--polystyrene (PBMA--PS) and poly[-(4-vinylbenzyl)-,-diethylamine]--polystyrene (PVEA--PS) is achieved. These MCBNs contain a PS core and discrete PVEA and/or PBMA nodules on the PS core. By changing the ratio of the two macro-RAFT agents or the polymerization degree of the solvophobic block in the two diblock copolymer mixture, the structure of MCBNs can be tuned. Our strategy overcomes the inconvenience and difficulty in synthesis of MCBNs, and it introduces a valid way to prepare well-defined MCBNs constructed with two or more diblock copolymers.