Department of Neurology and Neuroscience Center, the First Hospital of Jilin University, Changchun, Jilin, China.
Department of Ophthalmology, the Second Hospital of Jilin University, Changchun, Jilin, China.
Expert Rev Clin Pharmacol. 2022 Apr;15(4):433-442. doi: 10.1080/17512433.2022.2081151. Epub 2022 May 31.
Recent studies have found potential benefits of vitamin D in relieving pain, and the results from randomized controlled trials of vitamin D for fibromyalgia have been promising. We conducted a comprehensive systematic review and meta-analysis to evaluate the efficacy of vitamin D for treating fibromyalgia.
PubMed, Web of Science, Embase, and Cochrane Library databases were systematically searched for English-language articles. Based on the inclusion and exclusion criteria, we selected only randomized controlled studies that reported vitamin D versus placebo-controlled cure for fibromyalgia. After extracting valid data, a meta-analysis was performed using Stata 12.0. The major outcome in the pooled analysis was the Fibromyalgia Impact Questionnaire and Visual Analogue Scale (VAS) changes.
Five studies including 315 participants were identified. These studies found that vitamin D was effective in reducing Fibromyalgia Impact Questionnaire scores compared with those of the control group, with significant differences (weighted mean difference = -7.82, 95% confidence interval: -12.05 to -3.59, P < 0.001). However, there was no statistical difference in VAS between the two groups (weighted mean difference = -0.60, 95% confidence interval: -1.38 to 0.17, P > 0.05).
Vitamin D supplementation may be an effective fibromyalgia therapeutic approach.
最近的研究发现维生素 D 在缓解疼痛方面具有潜在的益处，并且维生素 D 治疗纤维肌痛的随机对照试验结果令人鼓舞。我们进行了一项全面的系统评价和荟萃分析，以评估维生素 D 治疗纤维肌痛的疗效。
系统检索了 PubMed、Web of Science、Embase 和 Cochrane Library 数据库中的英文文献。根据纳入和排除标准，我们仅选择了报告维生素 D 与安慰剂对照治疗纤维肌痛的随机对照研究。提取有效数据后，使用 Stata 12.0 进行荟萃分析。汇总分析中的主要结局是纤维肌痛影响问卷和视觉模拟量表 (VAS) 的变化。
确定了五项研究，共 315 名参与者。这些研究发现，与对照组相比，维生素 D 治疗可有效降低纤维肌痛影响问卷评分，差异具有统计学意义（加权均数差=-7.82，95%置信区间：-12.05 至-3.59，P<0.001）。然而，两组间 VAS 无统计学差异（加权均数差=-0.60，95%置信区间：-1.38 至 0.17，P>0.05）。
维生素 D 补充可能是一种有效的纤维肌痛治疗方法。
