Department of Otolaryngology Head and Neck Surgery, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, Guangdong, People's Republic of China.
Department of Thyroid Center/Thyroid Surgery, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, Guangdong, People's Republic of China.
Eur Arch Otorhinolaryngol. 2022 Sep;279(9):4587-4594. doi: 10.1007/s00405-022-07403-w. Epub 2022 May 21.
This study aimed to explore the prognostic value of thyroid invasion of parathyroid carcinoma without lymph node or distant metastasis.
Two hundred and nine cases of parathyroid carcinoma from the SEER (1989-2014) were eligible for this study. A Chi-squared test, t test, X-tile, Kaplan-Meier curves, and multivariate Cox proportional hazard regression were used for analysis.
Thyroid invasion, sex, race, age, radiation, and surgery were not significantly associated with cancer-specific survival by multivariate analysis. However, tumor size ≥ 4 cm was significantly associated with worse cancer-specific survival (P < 0.001).
Thyroid invasion, which was the criterion for T and T staging criteria of parathyroid carcinoma according to the AJCC, did not affect the prognosis of patients with parathyroid carcinoma without local lymph node or distant metastasis. Our study indicates that a tumor size ≥ 4 cm may be an appropriate indicator of T and T cancer staging.
本研究旨在探讨无局部淋巴结或远处转移的甲状旁腺癌侵犯甲状腺的预后价值。
本研究纳入了来自 SEER（1989-2014 年）的 209 例甲状旁腺癌患者。采用卡方检验、t 检验、X 片、Kaplan-Meier 曲线和多因素 Cox 比例风险回归进行分析。
多因素分析显示，甲状腺侵犯、性别、种族、年龄、放疗和手术与癌症特异性生存无显著相关性。然而，肿瘤大小≥4cm 与癌症特异性生存较差显著相关（P<0.001）。
根据 AJCC 的甲状旁腺癌 T 和 T 分期标准，甲状腺侵犯并不影响无局部淋巴结或远处转移的甲状旁腺癌患者的预后。我们的研究表明，肿瘤大小≥4cm 可能是 T 和 T 癌症分期的一个合适指标。
