Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA; Children's Nutrition Research Center, Houston, TX 77030, USA.
Res Dev Disabil. 2022 Aug;127:104257. doi: 10.1016/j.ridd.2022.104257. Epub 2022 May 18.
Smith-Magenis syndrome (SMS) is a complex neurodevelopmental disorder that includes obesity and food-seeking/satiety-related behaviors.
This study examined associations between food-related/hyperphagic behaviors, weight, and medication use in individuals with SMS.
METHODS/PROCEDURES: Caregivers of individuals with SMS in the Parents and Researchers Interested in SMS (PRISMS) Patient Registry completed a demographic/medication questionnaire, the Hyperphagia Questionnaire for Clinical Trials, and the Food Related Problems Questionnaire.
OUTCOMES/RESULTS: Among 49 participants (M = 16.41 ± 12.73 years, range = 4-69 years, 55% girls/women), individuals with SMS with overweight/obesity (n = 22) had worse overall food-related problems including greater impaired satiety (p < 0.05), maladaptive eating behaviors (p < 0.05), inappropriate response (p < 0.01), and hyperphagia (p < 0.01) compared to individuals of normal/underweight (n = 27). Those taking anti-depressants/anxiolytics (n = 16) had greater maladaptive eating behaviors (p < 0.05), hyperphagic behaviors (p < 0.05), and hyperphagic severity (p < 0.05) than those not taking anti-depressants/anxiolytics (n = 33). Boys/men with SMS had greater maladaptive eating behaviors (p < 0.05), inappropriate response (p < 0.05), and hyperphagic drive (p < 0.01) than girls/women with SMS.
CONCLUSIONS/IMPLICATIONS: Maladaptive food-related behaviors were higher in individuals with SMS with overweight/obesity, taking anti-depressants/anxiolytics, or who were male. Medications in this population should be chosen with weight-related side effects in mind.
Smith-Magenis 综合征（SMS）是一种复杂的神经发育障碍，包括肥胖和与食物寻求/饱腹感相关的行为。
本研究旨在探讨 SMS 个体的与食物相关/贪食行为、体重和药物使用之间的关系。
方法/程序：SMS 患者 PRISMS 患者登记处的患者照顾者完成了人口统计学/药物问卷、贪食问卷临床研究和食物相关问题问卷。
在 49 名参与者中（M = 16.41±12.73 岁，范围为 4-69 岁，55%为女孩/女性），超重/肥胖的 SMS 个体（n=22）与食物相关的整体问题更严重，包括更严重的饱食受损（p<0.05）、不良饮食习惯（p<0.05）、不适当的反应（p<0.01）和贪食（p<0.01）与体重正常/体重不足的个体（n=27）相比。服用抗抑郁药/抗焦虑药的个体（n=16）比未服用抗抑郁药/抗焦虑药的个体（n=33）具有更多的不良饮食习惯（p<0.05）、贪食行为（p<0.05）和贪食严重程度（p<0.05）。患有 SMS 的男孩/男性比患有 SMS 的女孩/女性具有更多的不良饮食习惯（p<0.05）、不适当的反应（p<0.05）和贪食驱动（p<0.01）。
结论/意义：超重/肥胖、服用抗抑郁药/抗焦虑药或男性 SMS 个体的与食物相关的行为更差。在该人群中选择药物时应考虑与体重相关的副作用。
