Key Laboratory of Traditional Chinese Korean Medicine Research (Yanbian University), State Ethnic Affairs Commission, College of Pharmacy, Yanbian University, Yanji, Jilin Province, 133002, China.
Key Laboratory of Traditional Chinese Korean Medicine Research (Yanbian University), State Ethnic Affairs Commission, College of Pharmacy, Yanbian University, Yanji, Jilin Province, 133002, China; Clinical Research Center, Affiliated Hospital of Yanbian University, Yanji, Jilin Province, 133002, China.
Phytochemistry. 2022 Aug;200:113247. doi: 10.1016/j.phytochem.2022.113247. Epub 2022 May 18.
Acanthoic acid (AA) is a pimaradiene diterpene isolated from the root bark of Acanthopanax koreanum Nakai (Araliaceae) with a wide range of pharmacological activities, including anti-cancer, anti-inflammatory, anti-diabetes, liver protection, gastrointestinal protection, and cardiovascular protection. In addition, AA promotes its pharmacological effects by targeting liver X receptors (LXRs), nuclear factor-kappa B (NF-κB), Toll-Like Receptor 4 (TLR4) and IL-1 receptor-associated kinase (IRAK) signaling pathways, or AMP-activated protein kinase (AMPK) signaling pathway, etc. Also, some studies focus on the structural modification of AA to improve its pharmacological activities. The review summarizes the pharmacological activities, molecular mechanism, and the structural modification of AA, which might supply information for the development of AA in the future.
刺囊酸（AA）是一种从刺五加根皮（五加科）中分离得到的枞烷二萜，具有广泛的药理活性，包括抗癌、抗炎、抗糖尿病、肝脏保护、胃肠道保护和心血管保护。此外，AA 通过靶向肝 X 受体（LXRs）、核因子-κB（NF-κB）、Toll 样受体 4（TLR4）和白细胞介素 1 受体相关激酶（IRAK）信号通路或 AMP 激活蛋白激酶（AMPK）信号通路等来促进其药理作用等。此外，一些研究还集中在 AA 的结构修饰上，以提高其药理活性。本综述总结了 AA 的药理活性、分子机制和结构修饰，为其未来的开发提供了信息。
