Arakawa S, Okumura M, Yamada S, Ito M, Tejima S
J Nutr Sci Vitaminol (Tokyo). 1986 Oct;32(5):481-5. doi: 10.3177/jnsv.32.481.
Since it has been demonstrated that a high level of fat is a dietary factor in the etiology of colon cancer, the effect of carrageenan, a polysaccharide extracted from the red seaweeds, on 1,2-dimethylhydrazine-induced colonic tumors in rats fed a semipurified control diet containing an ordinary level of fat was studied. Nevertheless, the enhancing effect of carrageenan on colonic tumors was observed. The rats fed a carrageenan diet had approximately twice the fecal weight compared to the rats fed a control diet. While no significant differences were found in beta-glucuronidase activities in colonic mucosa, liver or plasma in the carrageenan-fed rats and controls, the activity in feces was significantly lower in the carrageenan-fed rats. At least, no beta-glucuronidase activity seemed to be related to the tumor-enhancing effect of carrageenan.
由于高水平的脂肪已被证明是结肠癌病因中的一个饮食因素，因此研究了从红海藻中提取的多糖卡拉胶，对喂食含有普通脂肪水平的半纯化对照饮食的大鼠，在1,2 - 二甲基肼诱导的结肠肿瘤方面的影响。然而，观察到卡拉胶对结肠肿瘤有增强作用。喂食卡拉胶饮食的大鼠粪便重量约为喂食对照饮食大鼠的两倍。虽然喂食卡拉胶的大鼠和对照组在结肠黏膜、肝脏或血浆中的β-葡萄糖醛酸酶活性没有显著差异，但喂食卡拉胶的大鼠粪便中的活性显著较低。至少，似乎没有β-葡萄糖醛酸酶活性与卡拉胶的肿瘤增强作用相关。
