GDF15 和 Klotho 对肾脏的保护作用：物以类聚。

Renoprotection by GDF15 and Klotho: birds of a feather flock together.

机构信息

Division of Nephrology, Endocrinology and Metabolism, Tokai University School of Medicine, Isehara, Japan; Interactive Translational Research Center for Kidney Diseases, Tokai University School of Medicine, Isehara, Japan; The Institute of Medical Sciences, Tokai University, Isehara, Japan.

出版信息

Kidney Int. 2022 Jun;101(6):1112-1115. doi: 10.1016/j.kint.2022.04.007.

DOI:10.1016/j.kint.2022.04.007

PMID:35597591

Abstract

Growth differentiation factor 15 is a potential renoprotective factor whose expression is induced primarily at the proximal tubular site after kidney injury. Valiño-Rivas et al. confirmed the protective effect of growth differentiation factor 15 against different types of kidney injury and further identified that growth differentiation factor 15 also induces kidney expression of another renoprotective factor, Klotho. Surprisingly, Klotho expression is apparently enhanced in the proximal tubule, suggesting the cooperative action of the 2 renoprotective factors at this injury-prone site.

摘要

生长分化因子 15 是一种潜在的肾保护因子，其表达主要在肾损伤后近端小管部位被诱导。Valiño-Rivas 等人证实了生长分化因子 15 对不同类型肾损伤的保护作用，并进一步发现生长分化因子 15 还诱导肾脏表达另一种肾保护因子 Klotho。令人惊讶的是，Klotho 表达在近端小管中明显增强，表明这 2 种肾保护因子在这个易损伤部位具有协同作用。