Department of Clinical Sciences, Lund University, Lund, Sweden.
Division of Intensive and Perioperative Care, Skane University Hospital, Getingevägen 4, 22185, Lund, Sweden.
Sci Rep. 2022 May 21;12(1):8600. doi: 10.1038/s41598-022-12564-z.
An inserted central venous catheter (CVC) is considered foreign material by the inert host defence systems and induce inflammation and thrombus formation. The objective of this study was to evaluate blood compatibility of six commonly used CVCs. Three coated and three uncoated CVC materials were tested in a modified Chandler loop model. Each catheter material circulated in blood from ten different healthy volunteers for 1 h. Blood cell counts and measurements of the inert host defence systems were performed on blood samples from the loop. All the tested catheters demonstrated impact on blood cells, contact coagulation, the complement system, or inflammatory markers, although the impact varied significantly. Of the catheters we evaluated, the most unfavourable blood compatibility profile was found for the polyurethane CVC coated with chlorohexidine and silver sulfadiazine. The greatest variation in blood compatibility between test runs was noted for the silicone dialysis catheter. Poor blood compatibility should be taken seriously but given the experimental design of the current study the clinical significance remains to be evaluated.
插入的中心静脉导管（CVC）被惰性宿主防御系统视为异物，会引起炎症和血栓形成。本研究的目的是评估六种常用 CVC 的血液相容性。在改良的 Chandler 环模型中测试了三种涂层和三种未涂层的 CVC 材料。每种导管材料均从十个不同的健康志愿者的血液中循环 1 小时。从环中抽取血液样本，进行血细胞计数和惰性宿主防御系统的测量。所有测试的导管均对血细胞、接触性凝血、补体系统或炎症标志物产生影响，尽管影响程度差异很大。在所评估的导管中，氯己定和磺胺嘧啶银涂层的聚氨酯 CVC 的血液相容性最差。硅胶透析导管的血液相容性测试之间的差异最大。应认真对待血液相容性差的问题，但鉴于本研究的实验设计，其临床意义仍有待评估。
