甜菜碱可减轻慢性束缚应激引起的雄性小鼠睾丸损伤和氧化应激的变化。
Betaine attenuate chronic restraint stress-induced changes in testicular damage and oxidative stress in male mice.
机构信息
Clinical Anatomy & Reproductive Medicine Application Institute, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
Department of Physiology, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
出版信息
Reprod Biol Endocrinol. 2022 May 21;20(1):80. doi: 10.1186/s12958-022-00949-8.
SCOPE
Male fertility and sperm quality are negatively affected by psychological stress. Chronic restraint stress (CRS) is a common psychological stress that has a negative effect on sperm. Betaine (BET), an active ingredient isolated from Lycium barbarum, has anti-oxidant, anti-inflammatory and other pharmacological activities. This study aims to explore whether betaine has a therapeutic effect on sperm deformity and vitality under CRS and its mechanism.
METHODS AND RESULTS
Chronic restraint stress was induced in 8-week-old male C57BL/6 J mice by fixation for 6 h a day for 35 days. Mice were intraperitoneally injected with betaine (BET) or normal saline (NS) for 14 days. Thirty-five days later, the animals were sacrificed. The results showed that the detrimental effects of CRS on testes as evident by disrupted histoarchitecture, increased oxidative stress, inflammation and apoptosis that compromised male fertility. BET injections can reverse these symptoms.
CONCLUSIONS
BET can improve spermatogenesis dysfunction caused by CRS, which may provide potential dietary guidance.
范围
心理压力会对男性生育能力和精子质量产生负面影响。慢性束缚应激（CRS）是一种常见的心理应激，会对精子产生负面影响。甜菜碱（BET）是从枸杞中分离出的一种活性成分，具有抗氧化、抗炎等药理活性。本研究旨在探讨甜菜碱是否对 CRS 下的精子畸形和活力具有治疗作用及其机制。
方法和结果
通过每天固定 6 小时 35 天的方式诱导 8 周龄雄性 C57BL/6J 小鼠产生慢性束缚应激。用甜菜碱（BET）或生理盐水（NS）对小鼠进行腹腔注射 14 天。35 天后，处死动物。结果表明，CRS 对睾丸的组织学结构破坏、氧化应激增加、炎症和凋亡等不利影响，损害了男性生育能力。BET 注射可以逆转这些症状。
结论
BET 可改善 CRS 引起的生精功能障碍，可为饮食提供潜在的指导。
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