身体成分、脂肪分布与线粒体能量代谢之间关系的性别差异：一项初步研究。

Sex differences in the relationships between body composition, fat distribution, and mitochondrial energy metabolism: a pilot study.

作者信息

Bellissimo Moriah P, Fleischer Candace C, Reiter David A, Goss Amy M, Zhou Lei, Smith Matthew Ryan, Kohlmeier Jacob, Tirouvanziam Rabindra, Tran Phong H, Hao Li, Crain Benjamin H, Wells Greg D, Jones Dean P, Ziegler Thomas R, Alvarez Jessica A

机构信息

Pauley Heart Center, Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, USA.

Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.

出版信息

Nutr Metab (Lond). 2022 May 21;19(1):37. doi: 10.1186/s12986-022-00670-8.

DOI:10.1186/s12986-022-00670-8

PMID:35597962

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9123728/

Abstract

BACKGROUND

Adiposity and mitochondrial dysfunction are related factors contributing to metabolic disease development. This pilot study examined whether in vivo and ex vivo indices of mitochondrial metabolism were differentially associated with body composition in males and females.

METHODS

Thirty-four participants including 19 females (mean 27 yr) and 15 males (mean 29 yr) had body composition assessed by dual energy x-ray absorptiometry and magnetic resonance (MR) imaging. Monocyte reserve capacity and maximal oxygen consumption rate (OCR) were determined ex vivo using extracellular flux analysis. In vivo quadriceps mitochondrial function was measured using P-MR spectroscopy based on post-exercise recovery kinetics (τPCr). The homeostatic model assessment of insulin resistance (HOMA-IR) was calculated from fasting glucose and insulin levels. Variables were log-transformed, and Pearson correlations and partial correlations were used for analyses.

RESULTS

Mitochondrial metabolism was similar between sexes (p > 0.05). In males only, higher fat mass percent (FM%) was correlated with lower reserve capacity (r = - 0.73; p = 0.002) and reduced muscle mitochondrial function (r = 0.58, p = 0.02). Thigh subcutaneous adipose tissue was inversely related to reserve capacity in males (r = - 0.75, p = 0.001), but in females was correlated to higher maximal OCR (r = 0.48, p = 0.046), independent of FM. In females, lean mass was related to greater reserve capacity (r = 0.47, p = 0.04). In all participants, insulin (r = 0.35; p = 0.04) and HOMA-IR (r = 0.34; p = 0.05) were associated with a higher τPCr.

CONCLUSIONS

These novel findings demonstrate distinct sex-dependent associations between monocyte and skeletal muscle mitochondrial metabolism with body composition. With further study, increased understanding of these relationships may inform sex-specific interventions to improve mitochondrial function and metabolic health.

摘要

背景

肥胖和线粒体功能障碍是导致代谢性疾病发展的相关因素。这项初步研究探讨了线粒体代谢的体内和体外指标与男性和女性身体成分之间是否存在差异关联。

方法

34名参与者，包括19名女性（平均27岁）和15名男性（平均29岁），通过双能X线吸收法和磁共振成像评估身体成分。使用细胞外通量分析在体外测定单核细胞储备能力和最大耗氧率（OCR）。基于运动后恢复动力学（τPCr），使用磷磁共振波谱法测量体内股四头肌线粒体功能。根据空腹血糖和胰岛素水平计算胰岛素抵抗的稳态模型评估（HOMA-IR）。对变量进行对数转换，并使用Pearson相关性和偏相关性进行分析。

结果

两性之间的线粒体代谢相似（p>0.05）。仅在男性中，较高的体脂百分比（FM%）与较低的储备能力相关（r = -0.73；p = 0.002），且肌肉线粒体功能降低（r = 0.58，p = 0.02）。男性大腿皮下脂肪组织与储备能力呈负相关（r = -0.75，p = 0.001），但在女性中与较高的最大OCR相关（r = 0.48，p = 0.046），与FM无关。在女性中，瘦体重与更大的储备能力相关（r = 0.47，p = 0.04）。在所有参与者中，胰岛素（r = 0.35；p = 0.04）和HOMA-IR（r = 0.34；p = 0.05）与较高的τPCr相关。