Masuda M, Horisaka K
J Pharmacobiodyn. 1986 Nov;9(11):934-40. doi: 10.1248/bpb1978.9.934.
The effects of taurine (2-aminoethanesulfonic acid) and its homologue, homotaurine (3-aminopropanesulfonic acid), on biliary and fecal excretion of bile acids were investigated in dietary hyperlipidemic rats. Taurocholic acid was a major component in the bile of rats on laboratory chow and the ratio between glycine and taurine conjugated bile acids (G/T ratio) was 0.14. In feces, more free bile acids were present than in bile and the G/T ratio increased to 1.49. The biliary bile acid level increased approximately 2-fold in rats fed a diet containing 0.5% cholesterol and 1.0% cholic acid for 10 days. The glycine conjugated bile acid level increased approximately 7.5-fold, so that the G/T ratio was reversed to 1.17. the level of fecal bile acids increased approximately 19-fold while the G/T ratio remained at 1.43. Taurine or homotaurine (500 mg/kg/d each) was orally administered for 10 d concurrently with the cholesterol diet. Taurine suppressed elevation in the glycine conjugated bile acid level so the bile acid composition was roughly similar to that of the rats on laboratory chow and the G/T ratio became 0.06. In fecal excretion, the bile acid level increased significantly 1.2-fold over that of the control and the G/T ratio was 0.45. Homotaurine did not significantly alter the biliary bile acid level or the composition. These results indicated that taurine stimulated the excretion of bile acids, resulting in a reduction in serum cholesterol. Homotaurine did not influence bile acid metabolism.
研究了牛磺酸（2-氨基乙磺酸）及其同系物高牛磺酸（3-氨基丙烷磺酸）对饮食性高脂血症大鼠胆汁酸的胆汁排泄和粪便排泄的影响。牛磺胆酸是实验室饲料喂养大鼠胆汁中的主要成分，甘氨酸和牛磺酸结合胆汁酸的比例（G/T 比值）为 0.14。在粪便中，游离胆汁酸的含量比胆汁中多，G/T 比值增加到 1.49。在喂食含 0.5%胆固醇和 1.0%胆酸的饲料 10 天的大鼠中，胆汁胆汁酸水平增加了约 2 倍。甘氨酸结合胆汁酸水平增加了约 7.5 倍，因此 G/T 比值反转至 1.17。粪便胆汁酸水平增加了约 19 倍，而 G/T 比值保持在 1.43。在给予胆固醇饮食的同时，口服牛磺酸或高牛磺酸（各 500 mg/kg/d）10 天。牛磺酸抑制了甘氨酸结合胆汁酸水平的升高，因此胆汁酸组成与实验室饲料喂养的大鼠大致相似，G/T 比值变为 0.06。在粪便排泄中，胆汁酸水平比对照组显著增加了 1.2 倍，G/T 比值为 0.45。高牛磺酸对胆汁胆汁酸水平或组成没有显著影响。这些结果表明，牛磺酸刺激胆汁酸的排泄，导致血清胆固醇降低。高牛磺酸不影响胆汁酸代谢。
