Department of Psychology and Neuroscience, Dalhousie University, Halifax, NS, Canada.
J Alzheimers Dis. 2022;88(1):37-44. doi: 10.3233/JAD-220049.
Although Alzheimer's disease is most often studied in terms of memory impairments, olfactory dysfunction begins in the early stages. We tested olfactory learning, sensitivity, and response bias using signal detection methods in 12-month-old male and female 5xFAD mice and their wildtype controls in the operant olfactometer. Odor detection was not reduced in the 5xFAD mice, but learning was, which was worse in female 5xFAD mice than in males. Female mice were more conservative in their response strategy. Signal detection analysis allows us to discriminate between cognitive and sensory deficits of male and female mouse models of AD.
虽然阿尔茨海默病通常是从记忆障碍的角度进行研究，但嗅觉功能障碍在早期阶段就已经开始了。我们使用操作式嗅觉计，在 12 个月大的雄性和雌性 5xFAD 小鼠及其野生型对照中，使用信号检测方法测试了嗅觉学习、敏感性和反应偏向。在 5xFAD 小鼠中，嗅觉检测没有降低，但学习能力降低了，雌性 5xFAD 小鼠比雄性更差。雌性小鼠在反应策略上更为保守。信号检测分析使我们能够区分 AD 雄性和雌性小鼠模型的认知和感觉缺陷。
