Departments of Pediatrics, University of Tennessee Health Science Center, Memphis, TN, USA.
Department of Rehabilitation, Regional One Health, Memphis, TN, USA.
J Neonatal Perinatal Med. 2022;15(3):559-565. doi: 10.3233/NPM-220989.
Infants with in-utero exposure to opioids are at risk Neonatal Opioid Withdrawal Syndrome (NOWS) and non-pharmacological methods of care, like swaddling, quiet ambient environment are routinely recommended but are not systematically studied. We hypothesized that opioid exposed infants can tolerate whole body massage while hospitalized.
This is a prospective observational study (August 2017 to January 2019) and infants of mothers having a history of opioids use (OUD) were included. Infants received whole body massage for 30 minutes from birth till discharge home. Infants heart rate (HR), respiratory rate (RR), systolic (sBP) and diastolic blood pressure (dBP) were recorded prior to and at the end of massage session.
The pilot study enrolled 30 infants. The mean birth weight and gestational age were 38±1 weeks and 2868±523 grams, respectively. All massage sessions were well tolerated. There was marked decrease in HR, systolic and diastolic BP and RR, (p < 0.01) in all study infants post massage, more profound among infants with NOWS (p < 0.01) than without NOWS.
Whole body massage is very well tolerated by infants with in-utero opioid exposure. Infants with NOWS had marked decrease in their HR and BP from their baseline after massage.
在子宫内接触阿片类药物的婴儿有患新生儿阿片戒断综合征（NOWS）的风险，通常建议采用非药物护理方法，如襁褓、安静的环境，但这些方法并未得到系统研究。我们假设暴露于阿片类药物的婴儿在住院期间可以耐受全身按摩。
这是一项前瞻性观察研究（2017 年 8 月至 2019 年 1 月），纳入了有阿片类药物使用史（OUD）的母亲所生的婴儿。婴儿从出生到出院回家，每天接受 30 分钟的全身按摩。在按摩前和按摩结束时记录婴儿的心率（HR）、呼吸频率（RR）、收缩压（sBP）和舒张压（dBP）。
该试点研究纳入了 30 名婴儿。平均出生体重和胎龄分别为 38±1 周和 2868±523 克。所有的按摩疗程都能很好地耐受。所有研究婴儿在按摩后 HR、收缩压和舒张压以及 RR 均显著下降（p<0.01），有 NOWS 的婴儿下降更明显（p<0.01）。
全身按摩非常耐受子宫内接触阿片类药物的婴儿。有 NOWS 的婴儿在按摩后 HR 和血压明显低于基线。
