Peking Union Medical College Hospital of Peking Union Medical College and Chinese Academy of Medical Sciences, Department of Plastic Surgery, Beijing, China.
Department of Plastic Surgery, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, China.
J Cosmet Dermatol. 2022 Nov;21(11):5555-5561. doi: 10.1111/jocd.15106. Epub 2022 Jul 19.
Botulinum toxin type A (BoNT-A) injection is a popular cosmetic procedure in East Asian countries, and there are multiple types of toxins on the market. Whether different toxin types induce different changes in the masseter has not been studied.
We aimed to investigate and compare the changes induced by injection of different types of BoNT-A in the masseter.
Upon retrospective review of clinical records and routine ultrasound examination results of patients who underwent BoNT-A injection, four groups were set for comparison: unapproved toxin, OnabotulinumtoxinA, LanbotulinumtoxinA, and non-injected. Clinical records and ultrasound images were collected. Ultrasound images were taken in both horizontal and coronal planes. Elasticity of the masseter muscle was also investigated by measuring the surface wave speed.
A total of 24 patients were included (six patients per group). All patients were young females. For the non-injected group, the deep inferior tendon was clear and the muscle bundles were arranged, with little fibrous content. Patients who received unapproved toxin injection showed highly disarranged muscle and fiber bundles, with much fiber content present. The changes in OnabotulinumtoxinA and LanbotulinumtoxinA groups were in between those in the non-injected and unapproved toxin groups. Muscle rigidity was the highest in the unapproved toxin group, and generally higher in injected groups compared with the non-injected group.
Different types of BoNT-A may induce different changes in the masseter.
肉毒毒素 A 型（BoNT-A）注射是东亚国家流行的美容程序，市场上有多种类型的毒素。不同类型的毒素是否会引起咬肌的不同变化尚未研究。
我们旨在研究和比较不同类型的 BoNT-A 注射在咬肌中引起的变化。
通过回顾性审查接受 BoNT-A 注射的患者的临床记录和常规超声检查结果，将患者分为四组进行比较：未经批准的毒素、OnabotulinumtoxinA、LanbotulinumtoxinA 和未注射组。收集临床记录和超声图像。在水平和冠状平面拍摄超声图像。还通过测量表面波速度来研究咬肌的弹性。
共纳入 24 名患者（每组 6 名患者）。所有患者均为年轻女性。对于未注射组，深层下肌腱清晰，肌束排列整齐，纤维含量少。接受未经批准的毒素注射的患者表现出高度紊乱的肌肉和纤维束，纤维含量较多。OnabotulinumtoxinA 和 LanbotulinumtoxinA 组的变化介于未注射组和未经批准的毒素组之间。未批准毒素组的肌肉僵硬程度最高，与未注射组相比，一般在注射组中更高。
不同类型的 BoNT-A 可能会引起咬肌的不同变化。
