Grimm Teresa, Groß Martin, Nater Urs M, Summ Oliver, Kreutz Gunter
Public Health Department of the City of Oldenburg, Oldenburg, Germany.
Department of Music, Faculty of Linguistics and Cultural Studies, Carl von Ossietzky University, Oldenburg, Germany.
Front Neurol. 2022 May 6;13:788588. doi: 10.3389/fneur.2022.788588. eCollection 2022.
Various music interventions can evoke favorable behavioral responses or physiological reactions in people with disorders of consciousness (DOC), such as coma, unresponsive wakefulness syndrome (UWS), and minimally conscious state (MCS). However, it appears that no study thus far has investigated the effects of music on the endocrine system of people with DOC.
This explorative study aimed to investigate the effects of biographical music and biographical language on the physiological and endocrine systems of people with UWS and MCS.
A cohort of 20 people with DOC (10 women, 10 men; age range 19-77) received 20 min of biographical music and biographical language. Before and afterward, they were exposed to silence. Physiological and hormonal measurements were conducted before, during, and after the interventions.
Paired -tests showed a significant decrease of salivary cortisol in the condition with biographical language interventions.
Biographical interventions can modulate reactions in the endocrine system in people with DOC. Further studies are needed to establish whether and how individuals living with DOC show psychoneuroendocrine responses to music and other arts-based interventions.
各种音乐干预措施能够在意识障碍患者（如昏迷、无反应觉醒综合征（UWS）和最低意识状态（MCS））身上引发积极的行为反应或生理反应。然而，迄今为止似乎尚无研究调查音乐对意识障碍患者内分泌系统的影响。
这项探索性研究旨在调查个人生平音乐和个人生平语言对UWS和MCS患者生理及内分泌系统的影响。
一组20名意识障碍患者（10名女性，10名男性；年龄范围19 - 77岁）接受了20分钟的个人生平音乐和个人生平语言干预。在干预前后，他们处于安静环境中。在干预前、干预期间和干预后进行了生理和激素测量。
配对检验显示，在个人生平语言干预情况下，唾液皮质醇显著降低。
个人生平干预可以调节意识障碍患者内分泌系统的反应。需要进一步研究以确定意识障碍患者是否以及如何对音乐和其他基于艺术的干预措施表现出心理神经内分泌反应。
