Hay S, Garrett I R, Vernon-Roberts B, Cleary E G, Manthey B, Brooks P M
J Rheumatol. 1986 Dec;13(6):1007-13.
The effects of prednisolone and methotrexate on the histology and the content of collagen and proteoglycans of the inflammatory tissue in polyurethane sponges impregnated with heat killed M. tuberculosis and implanted subcutaneously in hooded Wistar rats for up to 63 days were studied. Drugs were administered during the 6-day period before sponge removal 7, 21, 35, 49 and 63 days after implantation. Our findings indicate that prednisolone and methotrexate have profound effects on the cellular events of acute and chronic inflammation, and influence the synthesis or degradation of connective tissue macromolecules at certain stages of the inflammatory process.
研究了泼尼松龙和甲氨蝶呤对在Wistar大鼠皮下植入含热灭活结核分枝杆菌的聚氨酯海绵达63天的炎性组织的组织学、胶原蛋白和蛋白聚糖含量的影响。在植入后7、21、35、49和63天海绵取出前的6天期间给药。我们的研究结果表明，泼尼松龙和甲氨蝶呤对急慢性炎症的细胞事件有深远影响，并在炎症过程的某些阶段影响结缔组织大分子的合成或降解。
