Babu Tirin, Panachiyil George Mathew, Vasudev Prajwala Hassan, Ravi Mandyam Dhati
Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru, Karnataka, India.
Department of Pediatrics, JSS Medical College and Hospital, JSS Academy of Higher Education & Research, Mysuru, Karnataka, India.
Hosp Pharm. 2022 Apr;57(2):237-240. doi: 10.1177/00185787211016332. Epub 2021 May 20.
Cefixime is a third-generation cephalosporin that has been used for the treatment of a wide range of infections in children and adults. The incidence of cefixime induced toxic epidermal necrolysis (TEN) is less than 2% in adults, but it is infrequent among pediatric patients. We report a rare case of cefixime induced TEN in a 7-year-old boy. In this case, the child presented with symptoms of TEN after 2 days of administration of cefixime. This case highlights the need to select structurally different antibiotics in case of antibiotic-induced severe cutaneous adverse reaction (SCAR) to avoid recurrence of SCAR. Furthermore, concluded that irrational use of antibiotics could be disastrous as it can result in TEN as the incidence of antibiotics induced TEN ranges from 29% to 42%.
头孢克肟是一种第三代头孢菌素，已用于治疗儿童和成人的多种感染。头孢克肟诱发中毒性表皮坏死松解症（TEN）的发生率在成人中低于2%，但在儿科患者中并不常见。我们报告一例7岁男孩罕见的头孢克肟诱发TEN病例。在此病例中，患儿在服用头孢克肟2天后出现TEN症状。该病例强调，在抗生素诱发严重皮肤不良反应（SCAR）的情况下，需要选择结构不同的抗生素以避免SCAR复发。此外，得出结论，不合理使用抗生素可能是灾难性的，因为这可能导致TEN，抗生素诱发TEN的发生率为29%至42%。
