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红细胞遗传异常与环境相互作用:在泰哈马特·阿西尔的一项研究。

Red cell genetic abnormalities and environmental interactions: a study in Tehamat Aseer.

作者信息

el-Hazmi M A

出版信息

J Trop Med Hyg. 1987 Apr;90(2):61-7.

PMID:3560299
Abstract

In a study conducted in the lowland areas of Tehamat Aseer and low mountainous areas of Al-Hepatah in the South Western Province of Saudi Arabia, different villages were screened for parasite infestation, anaemia prevalence and frequency of sickle cell (HbS) gene. The prevalence of alpha- and beta-thalassaemias and glucose-6-phosphate dehydrogenase (G-6-PD) deficiency were also investigated. The prevalence of anaemia was found to range between 3.5% and 9.1% in the different villages, while parasite infestation ranged from 0 to 36.4%. Sickle cell gene frequency was similar in the different villages, ranging between 0.06% and 0.11%. G-6-PD deficiency ranged from 8% to 14%, alpha-thalassaemia from 20% to 30% and beta-thalassaemia from 10% to 15%. Parasite infestation was found to be a major cause of anaemia in these populations.

摘要

在沙特阿拉伯西南部省份泰哈马特阿西尔的低地地区和哈帕塔的低山地区开展的一项研究中,对不同村庄进行了寄生虫感染、贫血患病率及镰状细胞(HbS)基因频率筛查。还调查了α和β地中海贫血以及葡萄糖-6-磷酸脱氢酶(G-6-PD)缺乏症的患病率。不同村庄的贫血患病率在3.5%至9.1%之间,而寄生虫感染率在0至36.4%之间。不同村庄的镰状细胞基因频率相似,在0.06%至0.11%之间。G-6-PD缺乏症患病率在8%至14%之间,α地中海贫血在20%至30%之间,β地中海贫血在10%至15%之间。研究发现,寄生虫感染是这些人群贫血的主要原因。

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