Department of Maternal and Child Health, Xiangya School of Public Health, Central South University, Changsha, China.
Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China.
Front Immunol. 2022 May 6;13:880298. doi: 10.3389/fimmu.2022.880298. eCollection 2022.
Inflammatory cytokines have been considered to be significant factors contributing to the development and progression of non-alcoholic fatty liver disease (NAFLD). However, the role of inflammatory cytokines in NAFLD remains inconclusive.
This study aimed to evaluate the association between inflammatory cytokines and NAFLD.
PubMed, Web of Science, the Cochrane Library, and EMBASE databases were searched until 31 December 2021 to identify eligible studies that reported the association of inflammatory cytokine with NAFLD and its subtypes. We pooled odds ratios (ORs) and hazard risk (HRs) with 95% confidence intervals (CIs) and conducted heterogeneity tests. Sensitivity analysis and analysis for publication bias were also carried out.
The search in the databases identified 51 relevant studies that investigated the association between 19 different inflammatory cytokines and NAFLD based on 36,074 patients and 47,052 controls. The results of the meta-analysis showed significant associations for C-reactive protein (CRP), interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and intercellular adhesion molecule-1 (ICAM-1) with NAFLD (ORs of 1.41, 1.08, 1.50, 1.15 and 2.17, respectively). In contrast, we observed non-significant associations for interferon-γ (IFN-γ), insulin-like growth factor (IGF-II), interleukin-2 (IL-2), interleukin-4 (IL-4), interleukin-5 (IL-5), interleukin-7 (IL-7), interleukin-8 (IL-8), interleukin-10 (IL-10), interleukin-12 (IL-12), monocyte chemoattractant protein-1(MCP-1), and transforming growth factor-β (TGF-β) with NAFLD. Our results also showed that CRP, IL-1β, and TNF-α were significantly associated with non-alcoholic steatohepatitis (NASH) and hepatic fibrosis.
Our results indicated that increased CRP, IL-1β, IL-6, TNF-α, and ICAM-1 concentrations were significantly associated with increased risks of NAFLD. These inflammatory mediators may serve as biomarkers for NAFLD subjects and expect to provide new insights into the aetiology of NAFLD as well as early diagnosis and intervention.
炎症细胞因子被认为是导致非酒精性脂肪性肝病（NAFLD）发生和发展的重要因素。然而，炎症细胞因子在 NAFLD 中的作用仍存在争议。
本研究旨在评估炎症细胞因子与 NAFLD 之间的关系。
检索 PubMed、Web of Science、Cochrane 图书馆和 EMBASE 数据库，检索时间截至 2021 年 12 月 31 日，以确定报告炎症细胞因子与 NAFLD 及其亚型相关性的合格研究。我们汇总了优势比（OR）和风险比（HR）及其 95%置信区间（CI），并进行了异质性检验。还进行了敏感性分析和发表偏倚分析。
数据库检索共确定了 51 项相关研究，这些研究基于 36074 名患者和 47052 名对照，调查了 19 种不同炎症细胞因子与 NAFLD 的关系。荟萃分析结果显示，C 反应蛋白（CRP）、白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）和细胞间黏附分子-1（ICAM-1）与 NAFLD 显著相关（OR 分别为 1.41、1.08、1.50、1.15 和 2.17）。相比之下，我们观察到干扰素-γ（IFN-γ）、胰岛素样生长因子-II（IGF-II）、白细胞介素-2（IL-2）、白细胞介素-4（IL-4）、白细胞介素-5（IL-5）、白细胞介素-7（IL-7）、白细胞介素-8（IL-8）、白细胞介素-10（IL-10）、白细胞介素-12（IL-12）、单核细胞趋化蛋白-1（MCP-1）和转化生长因子-β（TGF-β）与 NAFLD 无显著相关性。我们的研究结果还表明，CRP、IL-1β 和 TNF-α与非酒精性脂肪性肝炎（NASH）和肝纤维化显著相关。
我们的结果表明，CRP、IL-1β、IL-6、TNF-α 和 ICAM-1 浓度升高与 NAFLD 风险增加显著相关。这些炎症介质可能作为 NAFLD 患者的生物标志物，并有望为 NAFLD 的病因学以及早期诊断和干预提供新的见解。
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