Alshareef Mohammad, Alroqi Ahmad, Albaharna Hussain, Alsayed Ahmed, Alromaih Saud, Alrasheed Abdulaziz S, Ajlan Abdulrazag, Alsaleh Saad
Department of Otolaryngology-Head and Neck Surgery, Khamis Mushait General hospital - Khamis Mushait City, Saudi Arabia.
Department of Otolaryngology-Head and Neck Surgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Ear Nose Throat J. 2025 Mar;104(3):176-182. doi: 10.1177/01455613221099483. Epub 2022 May 21.
Recently, endoscopic endonasal approaches (EEA) have been used for skull base defect reconstruction surgeries. The nasoseptal flap (NSF), a vascular pedicled flap, was introduced to decrease postoperative cerebrospinal fluid (CSF) leakage.
This study aimed to outline the authors' institutional experience using NSF and rigid implants in anterior skull base defect reconstruction surgeries following EEA.
A retrospective cohort review of patients who underwent NSF reconstruction following EEA in the Otorhinolaryngology and Neurosurgery Departments at King Saud University Medical City, Riyadh, Saudi Arabia, from January 2015 to May 2021, divided into 2 time periods according to the reconstruction technique.
Out of the 106 patients who underwent EEA, 77 underwent NSF reconstruction. The majority had expanded EEA (94.8%). The mean age was 40.21 ± 17.7 years, and the female gender represented 61% of the sample. More than half of the sample underwent right NSF (57.1%). Meningioma was the most common diagnosis (45.5%). The clivus was the most frequent site of lesions (23.4%). The overall rate of postoperative CSF leakage and lumbar drainage (LD) insertion was 15.6% and 51.9%, respectively. The duration of LD was a median of four days. The overall failure rate was 13%, declining from 20% in the first period to 5.4% in the second period. Rigid implants were used significantly more in the first period than in the second period (67.5% versus 16.2%, < 0.001). Meningitis, the highest postoperative complication, was reported in 6 patients (7.8%). One patient died three weeks postoperatively after massive nasal bleeding. No significant difference was found between either side of the NFS regarding the CSF leakage and failure rate.
In the authors' experience, there has been an overt decline in failure rates and complications of EEA over the last three years due to increased experience among surgeons and a standardization of reconstruction techniques. Minimal reconstruction may provide satisfactory results by decreasing the use of rigid implants. An endoscopic endonasal approach with an NSF for anterior skull base defect reconstruction is considered a safe procedure with no significant difference between the sides of the flap.
最近,鼻内镜鼻内入路(EEA)已用于颅底缺损修复手术。鼻隔瓣(NSF)作为一种带血管蒂的皮瓣被引入,以减少术后脑脊液(CSF)漏。
本研究旨在概述作者所在机构在EEA术后前颅底缺损修复手术中使用NSF和刚性植入物的经验。
对2015年1月至2021年5月在沙特阿拉伯利雅得国王沙特大学医学城耳鼻喉科和神经外科接受EEA术后NSF修复的患者进行回顾性队列研究,根据修复技术分为2个时间段。
在106例接受EEA的患者中,77例接受了NSF修复。大多数患者采用扩大的EEA(94.8%)。平均年龄为40.21±17.7岁,女性占样本的61%。超过一半的样本采用右侧NSF(57.1%)。脑膜瘤是最常见的诊断(45.5%)。斜坡是最常见的病变部位(23.4%)。术后脑脊液漏和腰椎引流(LD)置入的总体发生率分别为15.6%和51.9%。LD的持续时间中位数为4天。总体失败率为13%,从第一阶段的20%降至第二阶段的5.4%。刚性植入物在第一阶段的使用明显多于第二阶段(67.5%对16.2%,<0.001)。6例患者(7.8%)出现了最高的术后并发症脑膜炎。1例患者术后三周因大量鼻出血死亡。NFS两侧在脑脊液漏和失败率方面未发现显著差异。
根据作者的经验,由于外科医生经验的增加和修复技术的标准化,在过去三年中EEA的失败率和并发症明显下降。通过减少刚性植入物的使用,微创修复可能会提供满意的结果。采用NSF的鼻内镜鼻内入路用于前颅底缺损修复被认为是一种安全的手术,皮瓣两侧无显著差异。