• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Targeting tumor hypoxia and hypoxia-inducible factors (HIFs) for the treatment of cancer- A story of transcription factors with novel approach in molecular medicine.

作者信息

Mukherjee Sukhes, Ray Suman Kumar

机构信息

Department of Biochemistry All India Institute of Medical Sciences Bhopal, Madhya Pradesh-462020 India.

Independent Researcher.

出版信息

Curr Mol Med. 2022;22(4):285-286. doi: 10.2174/156652402204220325161921.

DOI:10.2174/156652402204220325161921
PMID:35603885
Abstract
摘要

相似文献

1
Targeting tumor hypoxia and hypoxia-inducible factors (HIFs) for the treatment of cancer- A story of transcription factors with novel approach in molecular medicine.靶向肿瘤缺氧和缺氧诱导因子（HIFs）治疗癌症——分子医学中一种转录因子的新方法故事
Curr Mol Med. 2022;22(4):285-286. doi: 10.2174/156652402204220325161921.
2
Hypoxia-inducing factors as master regulators of stemness properties and altered metabolism of cancer- and metastasis-initiating cells.缺氧诱导因子作为干细胞特性和癌症起始细胞及转移起始细胞代谢改变的主要调节因子。
J Cell Mol Med. 2013 Jan;17(1):30-54. doi: 10.1111/jcmm.12004. Epub 2013 Jan 10.
3
Progress on hypoxia-inducible factor-3: Its structure, gene regulation and biological function (Review).缺氧诱导因子-3的研究进展：其结构、基因调控及生物学功能（综述）
Mol Med Rep. 2015 Aug;12(2):2411-6. doi: 10.3892/mmr.2015.3689. Epub 2015 Apr 27.
4
Hypoxia-mediated drug resistance: novel insights on the functional interaction of HIFs and cell death pathways.缺氧介导的耐药性：HIFs 和细胞死亡途径功能相互作用的新见解。
Drug Resist Updat. 2011 Jun;14(3):191-201. doi: 10.1016/j.drup.2011.03.001. Epub 2011 Apr 3.
5
Assessment of Stabilization and Activity of the HIFs Important for Hypoxia-Induced Signalling in Cancer Cells.评估对癌细胞中缺氧诱导信号传导至关重要的低氧诱导因子的稳定性和活性。
Methods Mol Biol. 2019;1928:77-99. doi: 10.1007/978-1-4939-9027-6_6.
6
Hypoxia-inducible factors not only regulate but also are myeloid-cell treatment targets.缺氧诱导因子不仅起调节作用，也是髓系细胞的治疗靶点。
J Leukoc Biol. 2021 Jul;110(1):61-75. doi: 10.1002/JLB.4RI0820-535R. Epub 2020 Oct 18.
7
The role of hypoxia-inducible factors in tumorigenesis.缺氧诱导因子在肿瘤发生中的作用。
Cell Death Differ. 2008 Apr;15(4):678-85. doi: 10.1038/cdd.2008.21. Epub 2008 Feb 15.
8
Expression of the forkhead transcription factor FOXP1 is associated both with hypoxia inducible factors (HIFs) and the androgen receptor in prostate cancer but is not directly regulated by androgens or hypoxia.叉头转录因子FOXP1的表达与前列腺癌中的缺氧诱导因子（HIFs）和雄激素受体均相关，但不受雄激素或缺氧的直接调控。
Prostate. 2007 Jul 1;67(10):1091-8. doi: 10.1002/pros.20583.
9
Regulation of hypoxia-inducible gene expression after HIF activation.缺氧诱导因子激活后缺氧诱导基因表达的调控。
Exp Cell Res. 2017 Jul 15;356(2):182-186. doi: 10.1016/j.yexcr.2017.03.013. Epub 2017 Mar 9.
10
The hypoxia-associated factor switches cells from HIF-1α- to HIF-2α-dependent signaling promoting stem cell characteristics, aggressive tumor growth and invasion.缺氧相关因子促使细胞从 HIF-1α 依赖性信号转导切换为 HIF-2α 依赖性信号转导，促进干细胞特性、侵袭性肿瘤生长和侵袭。
Cancer Res. 2011 Jun 1;71(11):4015-27. doi: 10.1158/0008-5472.CAN-10-4142. Epub 2011 Apr 21.

引用本文的文献

1
Transcription factor TCF7L1 targeting HSPB6 is involved in EMT and PI3K/AKT/mTOR pathways in bladder cancer.靶向热休克蛋白B6的转录因子TCF7L1参与膀胱癌的上皮-间质转化及PI3K/AKT/mTOR信号通路。
J Biol Chem. 2025 Jan;301(1):108024. doi: 10.1016/j.jbc.2024.108024. Epub 2024 Nov 26.
2
Limning of HIF-2 and HIF-3 in the Tumor Microenvironment: Developing Concepts for the Treatment of Hypoxic Cancer.肿瘤微环境中HIF-2和HIF-3概述：缺氧癌症治疗的发展概念
Curr Mol Med. 2024 May 17. doi: 10.2174/0115665240303179240427071748.
3
Hyperoxic-hypoxic Paradox: Breast Cancer Microenvironment and an Innovative Treatment Strategy.
高氧-低氧悖论：乳腺癌微环境与创新治疗策略。
Anticancer Agents Med Chem. 2024;24(10):729-732. doi: 10.2174/0118715206290816240220062545.
4
Innovative Nanomaterials for Targeting Hypoxia to Improve Treatment for Triple-negative Breast Cancer.用于靶向缺氧以改善三阴性乳腺癌治疗的创新纳米材料。
Recent Pat Biotechnol. 2024;18(4):269-272. doi: 10.2174/0118722083270521231027074157.