Heimbach D M, Engrav L H, Marvin J A, Harnar T J, Grube B J
JAMA. 1987 Apr 24;257(16):2171-5.
Toxic epidermal necrolysis is an uncommon but severe form of epidermal sloughing with associated mucositis. Treated in a general hospital, it carries a high mortality (25% to 70%) and substantial long-term morbidity. If the patient is referred early to a burn center, where it can be treated with biologic dressings and intensive support care, the mortality can be reduced below 20% and there may be negligible long-term morbidity. We describe 19 patients so treated, with three deaths and no long-term complications.
中毒性表皮坏死松解症是一种罕见但严重的伴有黏膜炎症的表皮脱落形式。在综合医院进行治疗时，其死亡率很高（25%至70%），且长期发病率也很高。如果患者能早期转诊至烧伤中心，在那里可采用生物敷料和强化支持治疗，死亡率可降至20%以下，长期发病率可能微乎其微。我们描述了19例接受如此治疗的患者，其中3例死亡，且无长期并发症。
