Department of Internal Medicine, University of Health Sciences, Tepecik Training and Research Hospital, Izmir, Turkey.
Department of Endocrinology, University of Health Sciences, Kocaeli Derince Training and Research Hospital, Turkey.
Gynecol Endocrinol. 2022 Jul;38(7):588-591. doi: 10.1080/09513590.2022.2076832. Epub 2022 May 23.
This study aims to determine the effect of serum free triiodothyronine (fT3), free thyroxine (fT4), thyroid-stimulating hormone (TSH) and fT3/fT4 ratio on the gestational diabetes.
This multicenter study was conducted by analyzing retrospectively 495 pregnant women who admitted to the Tepecik training and Research Hospital, and Kocaeli Derince training and Research Hospital between January 2017 and December 2019. Seventy-eight pregnant women diagnosed with Gestational Diabetes Mellitus (GDM) and 82 pregnant women without GDM diagnosis were included in the study. The relationship between thyroid markers (TSH, fT3, fT4 and fT3/fT4) and gestational diabetes was determined using logistic regression analysis.
Advanced age, low fT4 and high TSH levels were higher in GDM group, < .05. Results of the logistic regression analysis revealed that the gestational week (OR 20.291, 95% CI 3.132-131-449, = .002], fasting plasma glucose (OR 48,551, 95% CI 9.223-255.582, < .001), HbA1c (OR 13,671, 95%CI 2.977-62.781, =.001) and fT3/fT4 (OR 29.934, 95% CI 3.558-251836, = .002) were the risk factors of GDM.
Advanced gestational week, fasting blood glucose, HbA1c and fT3/fT4 ratio are among the risk factors for the development of the gestational diabetes.
本研究旨在探讨血清游离三碘甲状腺原氨酸（fT3）、游离甲状腺素（fT4）、促甲状腺激素（TSH）和 fT3/fT4 比值对妊娠期糖尿病的影响。
本多中心研究回顾性分析了 2017 年 1 月至 2019 年 12 月期间在 Tepecik 培训与研究医院和 Kocaeli Derince 培训与研究医院就诊的 495 名孕妇。本研究纳入了 78 例被诊断为妊娠期糖尿病（GDM）的孕妇和 82 例未被诊断为 GDM 的孕妇。采用 logistic 回归分析确定甲状腺标志物（TSH、fT3、fT4 和 fT3/fT4）与妊娠期糖尿病之间的关系。
GDM 组患者的年龄较大，fT4 较低，TSH 水平较高，差异有统计学意义（均 < .05）。logistic 回归分析结果显示，孕龄（OR 20.291，95%CI 3.132-131-449， = .002]）、空腹血糖（OR 48，551，95%CI 9.223-255.582， < .001]）、HbA1c（OR 13，671，95%CI 2.977-62.781， =.001]）和 fT3/fT4（OR 29.934，95%CI 3.558-251836， = .002]）是 GDM 的危险因素。
孕龄较大、空腹血糖、HbA1c 和 fT3/fT4 比值是妊娠期糖尿病发生的危险因素。
