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胫骨转移瘤的外科治疗:系统评价。

Surgical management of tibial metastases: a systematic review.

机构信息

Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy. Università Cattolica del Sacro Cuore, Roma, Italia..

Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy. Università Cattolica del Sacro Cuore, Roma, Italia.";}.

出版信息

Acta Biomed. 2022 Mar 10;92(S3):e2021552. doi: 10.23750/abm.v92iS3.12540.

Abstract

BACKGROUND

Tibia is a rare location among all skeletal metastases. Those lesions are often discovered in an advanced stage of disease and are mainly reported to the orthopedic surgeon to reduce pain, to improve the patient quality of life and his functional status. Current literature on the surgical management of metastases and/or pathological tibial fractures shows mostly few case reports, case series or at most retrospective studies on very small and heterogeneous groups of patients. The purpose of this study is to analyze those articles highlighting epidemiology and discussing surgical options and relative outcomes.

METHODS

Studies were searched on PubMed, Google Scholar and Web of Knowledge from inception to September 2020 and 30 articles discussing tibial metastasis surgical treatment were included.

RESULTS

Results discuss age and sex of patients, location of tibial metastases, origin of metastases, type of lesion and spread of disease, surgical treatment, outcomes in terms of pain evolution, gain of function and general status, complication and relapse, and survival of patients.

CONCLUSIONS

Despite the lack of randomized trials and the absence of high-level studies, guidelines suggest different types of treatments depending on location and stage of disease. The analysis of the articles included in this review confirms the heterogeneity of possible treatments, assuring, independently of the chosen techniques, good and similar results, leading to the conclusion that the choice of the surgical technique must take in consideration each patient's characteristics and the surgeon's experience.

摘要

背景

胫骨是所有骨骼转移中罕见的部位。这些病变通常在疾病的晚期被发现,主要向骨科医生报告,以减轻疼痛,提高患者的生活质量和功能状态。目前关于转移瘤和/或病理性胫骨骨折的手术治疗的文献主要是少数病例报告、病例系列或最多是针对非常小且异质患者群体的回顾性研究。本研究的目的是分析这些文章,重点介绍流行病学,并讨论手术选择和相关结果。

方法

从建立到 2020 年 9 月,在 PubMed、Google Scholar 和 Web of Knowledge 上搜索研究,共纳入 30 篇讨论胫骨转移瘤手术治疗的文章。

结果

结果讨论了患者的年龄和性别、胫骨转移的位置、转移的来源、病变的类型和疾病的扩散、手术治疗、疼痛演变、功能获得和一般状况、并发症和复发以及患者的生存情况。

结论

尽管缺乏随机试验和缺乏高级别研究,指南建议根据疾病的位置和阶段采用不同类型的治疗方法。对纳入本综述的文章的分析证实了可能的治疗方法存在异质性,独立于所选技术,均能取得良好且相似的结果,从而得出结论,手术技术的选择必须考虑到每个患者的特点和外科医生的经验。

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