Coury Josephine R, Morrissette Cole R, Lee Nathan J, Cerpa Meghan, Sardar Zeeshan M, Weidenbaum Mark, Lehman Ronald A, Lombardi Joseph M, Lenke Lawrence G
Och Spine Hospital, New York-Presbyterian/Columbia University Irving Medical Center, New York, NY, USA.
Global Spine J. 2024 Mar;14(2):364-369. doi: 10.1177/21925682221104425. Epub 2022 May 23.
Retrospective Cohort Study.
Few previous studies have examined the relationship between preoperative disability and patient outcomes after complex adult spinal deformity surgery. In this study, we hypothesized that patients with worse preoperative disability would be more likely achieve a clinically significant improvement in their symptoms after surgery.
Demographics, comorbidities, surgical data, and health related survey results were analyzed from a consecutive series of adults (≥18 years old) who underwent spinal deformity correction, instrumentation, and fusion. Patients included had 6 or more levels fused and their surgery performed at single institution between 2015 and 2018 with minimum 2 year follow up.
A total of 108 patients met inclusion criteria. Bivariate analysis demonstrated the following as having a greater probability of reaching minimum clinically important difference (MCID) at 2 years postoperatively: >50 percentile Oswestry Disability Index (ODI) score (ODI >36), cardiac comorbidities, and use of pelvic fixation, pedicle subtraction osteotomy, and transforaminal lumbar interbody fusion. Conversely, baseline Scoliosis research society score (SRS) >50 percentile (SRS ≥62) and use of vertebral column resection (VCR) were significant predictors of not reaching MCID at 2 years. On logistic regression analysis, >50 percentile ODI score (ODI >36) was identified as the only independent predictor of achieving MCID.
Patients with greater disability, independent of other preoperative or surgical factors, are more likely to have clinically significant improvement in their daily functioning after complex deformity surgery. For patients who undergo surgical intervention for severe or progressive deformity, including VCR, MCID might be an ineffective outcome measure.
回顾性队列研究。
以往很少有研究探讨复杂成人脊柱畸形手术后术前残疾与患者预后之间的关系。在本研究中,我们假设术前残疾程度较重的患者术后症状更有可能获得具有临床意义的改善。
对一系列连续接受脊柱畸形矫正、内固定和融合手术的成年人(≥18岁)的人口统计学、合并症、手术数据以及健康相关调查结果进行分析。纳入的患者融合节段为6个或更多,于2015年至2018年在单一机构接受手术,且随访时间至少为2年。
共有108例患者符合纳入标准。双变量分析表明,以下因素在术后2年达到最小临床重要差异(MCID)的可能性更大:Oswestry功能障碍指数(ODI)评分>第50百分位数(ODI>36)、心脏合并症,以及使用骨盆固定、椎弓根截骨术和经椎间孔腰椎椎间融合术。相反,基线脊柱侧凸研究学会评分(SRS)>第50百分位数(SRS≥62)以及使用脊柱椎体切除术(VCR)是术后2年未达到MCID的显著预测因素。逻辑回归分析显示,ODI评分>第50百分位数(ODI>36)是实现MCID的唯一独立预测因素。
残疾程度较高的患者,独立于其他术前或手术因素,在复杂畸形手术后日常功能更有可能获得具有临床意义的改善。对于接受严重或进展性畸形手术干预(包括VCR)的患者,MCID可能是一个无效的结局指标。