Abbakumov V V, Lebedeva R N, Eremenko A A, Podlesskikh Iu S, Mikhaĭlov Iu M
Kardiologiia. 1986 Dec;26(12):65-71.
Sympathomimetic agents: isoproterenol (novodrin), dopamine, noradrenalin, adrenalin were used in 137 patients with acute circulatory insufficiency. Their hemodynamic effects were assessed, using catheterization of heart chambers and radiocardiography, and studies of circulating blood oxygen transport, acid-base state and metabolic product levels. A differential approach to sympathomimetic treatment has been developed. Isoproterenol is primarily indicated in those cases where myocardial failure is combined with decreased heart rate, conductivity disorders and markedly increased total peripheral resistance. Dopamine is more justified in cases where increasing the heart rate is more desirable, and there are signs of renal failure and heart rhythm disorders. The possibility of dopamine-induced pulmonary hypertension and pO2 fall should not be dismissed. Correct choice of an agent or a combination of agents makes it possible to control the patient's condition through action on various hemodynamic mechanisms that determine the magnitude of cardiac output.
异丙肾上腺素（新福林）、多巴胺、去甲肾上腺素、肾上腺素用于137例急性循环功能不全患者。通过心腔插管和放射心电图评估其血流动力学效应，并研究循环血液氧运输、酸碱状态和代谢产物水平。已制定了拟交感神经药治疗的差异化方法。异丙肾上腺素主要适用于心肌衰竭合并心率降低、传导障碍和总外周阻力明显增加的情况。多巴胺在更希望增加心率且有肾衰竭和心律紊乱迹象的情况下更合理。不应忽视多巴胺诱发肺动脉高压和氧分压下降的可能性。正确选择一种药物或联合用药能够通过作用于决定心输出量大小的各种血流动力学机制来控制患者病情。
