Department of Physiotherapy and Rehabilitation, Faculty of Health Science, Istanbul Medipol University, Istanbul, Turkey.
Department of Ergotherapy, Faculty of Health Science, Istanbul Medipol University, Istanbul, Turkey.
Nutr Metab Cardiovasc Dis. 2022 Jul;32(7):1742-1752. doi: 10.1016/j.numecd.2022.04.017. Epub 2022 Apr 29.
To evaluate the effectiveness of structured exercise appropriate the circadian rhythm in terms of blood sample test (BST), functionality and quality of life (QoL) in individuals with type 2 diabetes.
This was a parallel-group, single-blind, crossover study. Thirty individuals with type 2 diabetes aged 35-65 years were enrolled in the study and allocated into 2 groups as the Morning Chronotype (MC) Group (n = 15) and the Evening Chronotype (EC) Group (n = 15) using Morningness-Eveningness Questionnaire which was used to determine the chronotypes. Participants were evaluated in terms of BST, functionality and QoL at the beginning of the study (T0), at 6 (T1), 12 (T2), and 18 (T3) weeks after the study started. A structured exercise program for 3 days a week over 6 weeks was applied in accordance with the chronotypes (T1-T2) and cross-controlled for the chronotypes (T2-T3). Significant differences were found in favor of the exercise given at the appropriate time for the chronotype in all parameters in both groups within groups (T0-T1-T2-T3) (p < 0.05). In the time∗group interactions, exercise in accordance with the appropriate chronotype in both groups provided the highest statistical improvement in all parameters (p < 0.05).
It was concluded that structured exercise performed at the appropriate time for chronotype improves HbA, fasting blood glucose, HDL-LDL cholesterol, triglyceride, total cholesterol, functionality and quality of life in type 2 diabetes. This variation in blood values was observed to reflect the quantitative effects of exercise administered according to the circadian rhythm in individuals with type 2 diabetes.
ClinicalTrials.gov (NCT04427488). The protocol of the study was registered at ClinicalTrials.gov (NCT04427488).
评估根据生物钟安排的结构化运动对 2 型糖尿病患者血液样本测试（BST）、功能和生活质量（QoL）的有效性。
这是一项平行组、单盲、交叉研究。30 名年龄在 35-65 岁的 2 型糖尿病患者参加了这项研究，并使用 Morningness-Eveningness Questionnaire 将他们分为晨型组（MC 组，n=15）和晚型组（EC 组，n=15）。参与者在研究开始时（T0）、6 周时（T1）、12 周时（T2）和 18 周时（T3）进行 BST、功能和 QoL 评估。根据生物钟（T1-T2）安排每周 3 天的结构化运动方案，并对生物钟进行交叉对照（T2-T3）。在两组内（T0-T1-T2-T3），在所有参数中，都发现了有利于按照生物钟安排的运动的显著差异（p<0.05）。在时间*组交互作用中，两组都按照生物钟安排运动，在所有参数中都提供了最高的统计学改善（p<0.05）。
结论是，按照生物钟安排的结构化运动可以改善 2 型糖尿病患者的 HbA、空腹血糖、HDL-LDL 胆固醇、甘油三酯、总胆固醇、功能和生活质量。在 2 型糖尿病患者中，这种血液值的变化被观察到反映了根据生物钟给予的运动的定量效果。
ClinicalTrials.gov（NCT04427488）。该研究的方案在 ClinicalTrials.gov 上注册（NCT04427488）。
