Kempe Kristian, Ng Sher Leen, Noi Ka Fung, Müllner Markus, Gunawan Sylvia T, Caruso Frank
Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010, Australia.
ACS Macro Lett. 2013 Dec 17;2(12):1069-1072. doi: 10.1021/mz400522e. Epub 2013 Nov 22.
Hollow polymer capsules were prepared from linear as well as brushlike poly(2-oxazoline)s (POxs). Linear POxs containing alkene functionalities were obtained by cationic ring-opening polymerization (CROP), whereas the brush POxs bearing alkyne moieties were synthesized by a combination of CROP and reversible addition-fragmentation chain transfer (RAFT) polymerization. Multilayers consisting of POx/poly(methacrylic acid) (PMA) were sequentially deposited onto silica particle templates, and the films were stabilized either by thiol-ene (TE) chemistry or copper-catalyzed azide-alkyne cycloaddition (CuAAc). Stable, monodisperse capsules were formed after removal of the silica particles with hydrofluoric acid and were observed using fluorescence and atomic force microscopy (AFM). Both architectures exhibited low-fouling behavior, an essential criteria for therapeutic carriers to be utilized in bioapplications. In particular, the brush-like POx capsules show potential as a viable alternative material for the fabrication of low-fouling capsules.
中空聚合物胶囊由线性以及刷状聚（2-恶唑啉）（POx）制备而成。含烯烃官能团的线性POx通过阳离子开环聚合（CROP）获得，而带有炔基部分的刷状POx则通过CROP与可逆加成-断裂链转移（RAFT）聚合相结合的方法合成。由POx/聚（甲基丙烯酸）（PMA）组成的多层膜依次沉积在二氧化硅颗粒模板上，这些膜通过硫醇-烯（TE）化学或铜催化的叠氮化物-炔烃环加成（CuAAc）进行稳定化处理。用氢氟酸去除二氧化硅颗粒后形成了稳定、单分散的胶囊，并使用荧光和原子力显微镜（AFM）进行观察。两种结构都表现出低污染行为，这是治疗载体用于生物应用的一个基本标准。特别是，刷状POx胶囊显示出作为制造低污染胶囊的可行替代材料的潜力。
