Wang Rui, Liu Xiao-Li, Jia Xiao-Jiao, Liu Yan, Lu Qiang
Department of Endocrinology, The First Hospital of Qinhuangdao, Qinhuangdao, Hebei Province, People's Republic of China.
Medical department, The First Hospital of Qinhuangdao, Qinhuangdao, Hebei Province, People's Republic of China.
Diabetes Metab Syndr Obes. 2022 May 17;15:1537-1542. doi: 10.2147/DMSO.S368504. eCollection 2022.
The purpose of this study was to explore the relationship between one-hour post-load plasma glucose levels and early arterial stiffness in subjects with different glucose tolerance.
This case-control study included 57 subjects with normal glucose tolerance, 38 subjects with pre-diabetes, and 30 subjects with type 2 diabetes. All subjects underwent an oral glucose tolerance test (OGTT) with 75 g of oral anhydrous glucose at 8:00 AM. The brachial-ankle pulse wave velocity (baPWV) was used as a surrogate marker of early arterial stiffness.
baPWV was significantly higher in the diabetes group than in the normal glucose tolerance group (diabetes group: 1501.8 ± 270.4 cm/s, pre-diabetes group: 1428.6 ± 173.1 cm/s vs normal glucose tolerance group: 1368.0 ± 242.8 cm/s) ( < 0.05). baPWV was positively correlated with age ( = 0.512, < 0.001), systolic blood pressure (SBP) ( = 0.526, < 0.001), diastolic blood pressure (DBP) ( = 0.298, = 0.001), fasting plasma glucose (FPG) ( = 0.213, = 0.017), 1-h plasma glucose levels from the OGTT ( = 0.407, < 0.001) and 2-h plasma glucose levels from the OGTT ( = 0.202, = 0.024). When baPWV was considered as the dependent variable in a multiple regression analysis, the 1-h plasma glucose level from the OGTT maintained an independent association with baPWV ( = 23.129, 95% CI: 8.142-38.115, = 0.003, R = 0.036).
The present study demonstrated the presence of early arterial stiffness in diabetes. Elevated 1-hour post-load plasma glucose level is closely related to the change of arterial elasticity in diabetes.
本研究旨在探讨不同糖耐量受试者负荷后1小时血糖水平与早期动脉僵硬度之间的关系。
本病例对照研究纳入57例糖耐量正常受试者、38例糖尿病前期受试者和30例2型糖尿病受试者。所有受试者于上午8:00口服75 g无水葡萄糖进行口服葡萄糖耐量试验（OGTT）。采用肱踝脉搏波速度（baPWV）作为早期动脉僵硬度的替代指标。
糖尿病组baPWV显著高于糖耐量正常组（糖尿病组：1501.8±270.4 cm/s，糖尿病前期组：1428.6±173.1 cm/s，糖耐量正常组：1368.0±242.8 cm/s）（<0.05）。baPWV与年龄（=0.512，<0.001）、收缩压（SBP）（=0.526，<0.001）、舒张压（DBP）（=0.298，=0.001）、空腹血糖（FPG）（=0.213，=0.017）、OGTT 1小时血糖水平（=0.407，<0.001）和OGTT 2小时血糖水平（=0.202，=0.024）呈正相关。在多元回归分析中，将baPWV作为因变量时，OGTT 1小时血糖水平与baPWV保持独立关联（=23.129，95%CI：8.142 - 38.115，=0.003，R = 0.036）。
本研究证明糖尿病患者存在早期动脉僵硬度。负荷后1小时血糖水平升高与糖尿病患者动脉弹性变化密切相关。
