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本文引用的文献

1
Evaluation of the Painful Total Knee Arthroplasty.疼痛性全膝关节置换术的评估。
J Am Acad Orthop Surg. 2019 Oct 15;27(20):743-751. doi: 10.5435/JAAOS-D-18-00083.
2
Evaluating the potential of kit-based 68Ga-ubiquicidin formulation in diagnosis of infection: a pilot study68Ga.评估基于试剂盒的68Ga-泛杀素制剂在感染诊断中的潜力：一项68Ga的初步研究
Nucl Med Commun. 2019 Mar;40(3):228-234. doi: 10.1097/MNM.0000000000000943.
3
Ga-NOTA-ubiquicidin fragment for PET imaging of infection: From bench to bedside.镓-NOTA-尿抑素片段用于感染的 PET 成像：从实验室到临床。
J Pharm Biomed Anal. 2018 Sep 10;159:245-251. doi: 10.1016/j.jpba.2018.06.064. Epub 2018 Jul 2.
4
Ga-NOTA-Functionalized Ubiquicidin: Cytotoxicity, Biodistribution, Radiation Dosimetry, and First-in-Human PET/CT Imaging of Infections.镓-NOTA 功能化尿抑素：细胞毒性、生物分布、辐射剂量学，以及感染的首例人体 PET/CT 成像。
J Nucl Med. 2018 Feb;59(2):334-339. doi: 10.2967/jnumed.117.200048. Epub 2017 Oct 19.
5
68Ga-DOTA Ubiquicidin PET/CT in an Infected Implant.68Ga-DOTA 尿抑素 PET/CT 在感染性植入物中的应用。
Clin Nucl Med. 2017 Feb;42(2):e115-e116. doi: 10.1097/RLU.0000000000001464.
6
Antimicrobial peptide 99mTc-ubiquicidin 29-41 as human infection-imaging agent: clinical trial.抗菌肽99mTc-泛素杀菌肽29-41作为人类感染显像剂：临床试验
J Nucl Med. 2005 Apr;46(4):567-73.

镓-氮杂环三胺-泛癸利定PET/CT成像上的感染性下肢大假体

Infected Lower Limb Megaprosthesis on Ga-NOTA-Ubiquicidin PET/CT Imaging.

作者信息

Kaushik Prateek, Maurya Satya Dev, Damle Nishikant, Ballal Sanjana, Kumar Venkatesan Sampath, Bal Chandrasekhar, Tripathi Madhavi

机构信息

Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.

Department of Orthopaedics, All India Institute of Medical Sciences, New Delhi, India.

出版信息

Nucl Med Mol Imaging. 2022 Jun;56(3):171-172. doi: 10.1007/s13139-022-00747-5. Epub 2022 Apr 11.

DOI:10.1007/s13139-022-00747-5
PMID:35607630
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9123113/
Abstract

Pain after prosthesis implant is a common clinical problem which requires distinction of septic from aseptic causes since the treatment differs. Non-invasive imaging methods play an important role in the diagnosis. Radiolabelled ubiquicidin can be used for imaging infection by binding directly to bacterial cell wall. We describe a case of a 24-year-old man with right lower limb megaprosthesis which did not show any loosening on computed tomography (CT) but was accurately diagnosed as infected prosthesis with Ga-NOTA-ubiquicidin(29-41) acetate scan.

摘要

假体植入后的疼痛是一个常见的临床问题，由于治疗方法不同，需要区分感染性和非感染性原因。非侵入性成像方法在诊断中起着重要作用。放射性标记的泛癸利定可通过直接结合细菌细胞壁用于感染成像。我们描述了一例24岁男性患者，其右下肢使用了大型假体，计算机断层扫描（CT）未显示任何松动，但通过醋酸镓-NOTA-泛癸利定（29-41）扫描准确诊断为假体感染。