Flemström G, Knutson L, Kivilaakso E
Klin Wochenschr. 1986;64 Suppl 7:107-11.
Bicarbonate secretion by the surface epithelium in the stomach and duodenum maintains a near neutral pH in the mucus gel adherent to the surface in spite of acidities as high as pH 2.0-3.0 in the gastric and pH 1.5-2.0 in the duodenal lumen. This strongly suggests that the alkaline secretion together with the mucus gel provides a first line of protection in the stomach and this may be the main mechanism of defense in the duodenum. The secretion is increased by physiological stimuli such as sham-feeding or the presence of acid in the lumen. Mucosal endogenous production of prostaglandins as well as humoral and neural mechanisms are involved in the control of the secretion.
胃和十二指肠表面上皮分泌的碳酸氢盐能使附着于表面的黏液凝胶保持接近中性的pH值，尽管胃内酸度高达pH 2.0 - 3.0，十二指肠腔内酸度高达pH 1.5 - 2.0。这有力地表明，碱性分泌物与黏液凝胶一起在胃中提供了第一道防线，这可能是十二指肠的主要防御机制。诸如假饲或腔内存在酸等生理刺激会增加这种分泌。黏膜内源性前列腺素的产生以及体液和神经机制参与了这种分泌的控制。
