Department of Anesthesiology, Nara Medical University, Nara, Japan.
Course of Perianesthesia Nursing, Graduate School of Nursing, Nara Medical University, Nara, Japan.
Asian J Anesthesiol. 2022 Jun 1;60(2). doi: 10.6859/aja.202204/PP.0002. Epub 2022 May 4.
Patients with alcohol drinking habits have less nausea and vomiting during chemotherapy because of cytochrome P450 enzyme induction. However, few studies have examined the effect of alcohol consumption on postoperative nausea and vomiting (PONV). We conducted a study to clarify the relationship between alcohol drinking habits and PONV.
Data of patients undergoing hepatectomy under general anesthesia between 2016 and 2020 were retrospectively collected. Since alcohol drinking habits vary by gender, age, and comorbidities, propensity score matching was performed to adjust patient background before multivariate logistic regression analysis.
Seventy-eight patients in the alcohol consumption and non-consumption groups were matched by propensity matching. Univariate analysis showed that alcohol consumption (P = 0.04) and male (P ＜ 0.001) were the factors that significantly reduced PONV. Multiple logistic regression analysis including intraoperative factors showed that alcohol consumption (odds ratio, 0.36; 95% confidence interval [CI], 0.15-0.90) and female (odds ratio, 5.34; 95% CI, 2.0-14.2) were associated with PONV as factors affecting PONV.
Patients with no alcohol drinking habits may be at higher risk of PONV.
由于细胞色素 P450 酶的诱导作用，有饮酒习惯的癌症患者在化疗期间恶心和呕吐的发生率较低。然而，很少有研究探讨饮酒习惯对术后恶心和呕吐（PONV）的影响。我们进行了一项研究，旨在阐明饮酒习惯与 PONV 之间的关系。
回顾性收集了 2016 年至 2020 年间接受全身麻醉下肝切除术的患者数据。由于饮酒习惯因性别、年龄和合并症而异，因此在进行多变量逻辑回归分析之前，进行了倾向评分匹配以调整患者背景。
通过倾向匹配，将饮酒组和非饮酒组各 78 例患者进行匹配。单因素分析显示，饮酒（P = 0.04）和男性（P ＜ 0.001）是显著降低 PONV 的因素。包括术中因素在内的多因素逻辑回归分析显示，饮酒（比值比，0.36；95%置信区间 [CI]，0.15-0.90）和女性（比值比，5.34；95% CI，2.0-14.2）是影响 PONV 的因素，与 PONV 相关。
无饮酒习惯的患者可能有更高的 PONV 风险。
