Department of Neurology, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu, Korea.
Department of Neurology, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea.
J Korean Med Sci. 2022 May 23;37(20):e160. doi: 10.3346/jkms.2022.37.e160.
Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 that may trigger Guillain-Barre syndrome (GBS) in selected patients. We describe a case of GBS presenting as marked finger extensor weakness in a 73-year-old woman with COVID-19. Her clinical and electrophysiological findings were consistent with a diagnosis of acute motor axonal neuropathy subtype of GBS with prominent finger dropping. Treatment with intravenous immunoglobulin for 5 days completely resolved her finger extension weakness after 19 months, although other involved extremities recovered earlier at 3 months. This study highlights that COVID-19-associated GBS can present in various forms aside from the classic variant, even in patients without any COVID-19 symptoms. Therefore, it is important to always consider the diagnosis of GBS in patients with COVID-19.
2019 年冠状病毒病(COVID-19)是一种由严重急性呼吸系统综合症冠状病毒 2 引起的传染病,可能在某些患者中引发吉兰-巴雷综合征(GBS)。我们描述了一例 GBS 病例,一名 73 岁女性 COVID-19 患者表现为明显的手指伸肌无力。她的临床和电生理表现符合急性运动轴索性神经病型 GBS 的诊断,伴有明显的手指下垂。静脉注射免疫球蛋白治疗 5 天,在 19 个月后完全缓解了她的手指伸展无力,尽管其他受累肢体在 3 个月时更早恢复。本研究强调,COVID-19 相关 GBS 除了经典变异型外,还可以呈现各种形式,甚至在没有任何 COVID-19 症状的患者中也是如此。因此,在 COVID-19 患者中始终考虑 GBS 的诊断非常重要。