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儿童椎体血管瘤的逐步治疗方法:病例报告及治疗算法建议

Stepwise approach for vertebral hemangioma in children: case-reports and treatment algorithm proposal.

作者信息

De Marco Raffaele, Piatelli Gianluca, Rossi Andrea, Nasto Luigi Aurelio, Pavanello Marco

机构信息

Department of Neurosurgery, IRCCS Istituto "G. Gaslini", via G. Gaslini 5, 16148, Genoa, Italy.

Neurosurgery Unit, Department of Neuroscience, "Rita Levi Montalcini", "Città Della Salute e Della Scienza" University Hospital, University of Turin, Via Cherasco 15, 10126, Turin, Italy.

出版信息

Eur Spine J. 2022 Dec;31(12):3748-3758. doi: 10.1007/s00586-022-07241-8. Epub 2022 May 24.

Abstract

PURPOSE

To discuss a treatment algorithm for vertebral hemangioma in children.

METHODS

Vertebral hemangioma (VH) is a rare cause of low back pain in children. In most cases, VHs present as incidental findings and do not require invasive diagnostic procedure. In case of symptomatic presentation, different approaches can be used. Over the years, we have developed a treatment algorithm for VH in children based on our clinical experience. In this manuscript, we propose a stepwise approach to treatment of VHs based on tumor extension and the degree of spinal cord/nerves compression with or without neurological deficit.

RESULTS

According to the proposed protocol, we discuss two cases of aggressive VH treated at our institution by a multidisciplinary team. The first case is about a young girl treated with percutaneous one-level posterior instrumentation followed by medical adjuvant therapy for an L4 "Stage 3" VH. The second case is about an 8-year-old boy with rapidly progressive myelopathy due to T11 "Stage 4" VH treated with a combined anterior and posterior surgery (i.e., posterior decompression and fusion followed by vertebrectomy and expandable cage placement) after preoperative arterial embolization.

CONCLUSION

Given the lack of international guidelines and consensus with regard to treatment of VHs in children, we believe our proposal for a stepwise approach combining clinical and radiological characteristics of the lesion may help guide treatment of this condition in children.

摘要

目的

探讨儿童椎体血管瘤的治疗方案。

方法

椎体血管瘤(VH)是儿童腰痛的罕见病因。在大多数情况下,VH为偶然发现,无需进行侵入性诊断程序。若出现症状,可采用不同的治疗方法。多年来,我们根据临床经验制定了儿童VH的治疗方案。在本文中,我们基于肿瘤扩展情况以及脊髓/神经受压程度(无论有无神经功能缺损),提出了一种针对VH的逐步治疗方法。

结果

根据所提出的方案,我们讨论了本机构多学科团队治疗的两例侵袭性VH病例。第一例是一名年轻女孩,因L4“3期”VH接受了经皮单节段后路内固定术,随后进行了药物辅助治疗。第二例是一名8岁男孩,因T11“4期”VH导致快速进展性脊髓病,术前进行动脉栓塞后,接受了前后联合手术(即后路减压融合术,随后进行椎体切除术和可扩张椎间融合器置入术)。

结论

鉴于目前缺乏关于儿童VH治疗的国际指南和共识,我们认为我们提出的结合病变临床和影像学特征的逐步治疗方法可能有助于指导儿童VH的治疗。

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