Thioether-Assisted Cu-Catalyzed C5-H Arylation of Imidazo[1,5-]pyridines.
作者信息
Wang Linhua, Zheng Xuesong, Zheng Qinze, Li Zhenlong, Wu Jian, Gao Ge
机构信息
Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, Sichuan University, 29 Wangjiang Road, Chengdu, Sichuan 610064, People's Republic of China.
出版信息
Org Lett. 2022 Jun 3;24(21):3834-3838. doi: 10.1021/acs.orglett.2c01404. Epub 2022 May 24.
PMID:35609286
Abstract
A Cu-catalyzed regioselective C5-H arylation of imidazo[1,5-]pyridines with aryl iodides was achieved with the assistance of an ethylthio group at the C3 position. This directing group could be easily removed to furnish a range of 5-(hetero)arylimidazo[1,5-]pyridine derivatives. The reaction tolerates a variety of functionalities and is compatible with sterically hindered substrates.
摘要
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