European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen (UMCG), University of Groningen (RUG), Groningen, The Netherlands; CellCOM Research Group, Instituto de Investigación Biomédica de A Coruña (INIBIC), Servizo Galego de Saúde (SERGAS), Universidade da Coruña (UDC), A Coruña, Spain.
European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen (UMCG), University of Groningen (RUG), Groningen, The Netherlands.
Curr Biol. 2022 May 23;32(10):R448-R452. doi: 10.1016/j.cub.2022.04.003.
Cellular senescence defines a state of stable and generally irreversible proliferative arrest associated with various morphological, structural and functional changes (Figure 1), including enhanced expression and secretion of pro-inflammatory and tissue-remodelling mediators. This state is crucial in tissue physiology and pathology and arises as a response to potentially damaging stress signals. Whether the activation of a senescence state provides benefits or detriments for tissue function and homeostasis is strictly dependent on the context. Cell senescence acts as a potent tumour-suppressive mechanism limiting the proliferation of cells at risk of malignant transformation and supports the repair of acute tissue damage, but also represents a key driver of ageing and age-related diseases.
细胞衰老定义了一种稳定且通常不可逆的增殖停滞状态，与各种形态、结构和功能变化相关（图 1），包括促炎和组织重塑介质的增强表达和分泌。这种状态在组织生理学和病理学中至关重要，是对潜在有害应激信号的反应。衰老状态的激活是否为组织功能和内稳态带来益处还是损害，严格取决于具体情况。细胞衰老作为一种有效的肿瘤抑制机制，限制了有恶性转化风险的细胞的增殖，并支持急性组织损伤的修复，但也是衰老和与年龄相关疾病的关键驱动因素。
