Šoša Ivan
Department of Anatomy, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia.
Pharmaceuticals (Basel). 2025 May 24;18(6):787. doi: 10.3390/ph18060787.
When cells remain permanently trapped in a particular cell cycle stage, they are in senescence. This also occurs in the liver. Such cells are often referred to as "zombie cells", and an entire organ filled with these "zombie cells" is said to be in a "zombie-like" state, characterized by a lack of function. The senescence-associated secretory phenotype (SASP) encompasses the substances these "zombie cells" release, which can significantly affect nearby cells and tissues. While cellular senescence and SASP are related concepts, they are distinct. This scoping review aims to clarify the role of hepatocyte senescence and hepatocyte SASP in the administration of pharmaceuticals, as well as their relevance to medico-legal practice, disability claims, and insurance coverage. In this context, the effects of pharmaceuticals on senescent hepatocytes are discussed, particularly regarding the medico-legal implications of substances likely to be abused. In conclusion, hepatocyte senescence may be relevant in clinical or medico-legal work because it sheds a new light on interpreting clinical findings and expert witness statements.
当细胞永久停滞在特定的细胞周期阶段时，它们就处于衰老状态。这种情况在肝脏中也会发生。这类细胞通常被称为“僵尸细胞”，而充满这些“僵尸细胞”的整个器官据说处于“类僵尸”状态，其特征是功能缺失。衰老相关分泌表型（SASP）包括这些“僵尸细胞”释放的物质，这些物质会对附近的细胞和组织产生显著影响。虽然细胞衰老和SASP是相关概念，但它们是不同的。本综述旨在阐明肝细胞衰老和肝细胞SASP在药物管理中的作用，以及它们与法医学实践、残疾索赔和保险覆盖范围的相关性。在此背景下，讨论了药物对衰老肝细胞的影响，特别是关于可能被滥用物质的法医学意义。总之，肝细胞衰老可能在临床或法医学工作中具有相关性，因为它为解释临床发现和专家证人陈述提供了新的视角。
